Detection of blaOXA-48 and clonal relationship in carbapenem resistant K-pneumoniae isolates at a tertiary care center in Western Turkey

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridEce, Cem/0000-0002-5786-0525
dc.authorwosidTerek Ece, Gulfem/IZQ-3909-2023
dc.authorwosidEce, Gulfem/AAN-7463-2020
dc.authorwosidEce, Gulfem/CAH-0765-2022
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidEce, Cem/AAS-7292-2021
dc.contributor.authorEce, Gulfem
dc.contributor.authorTunc, Emine
dc.contributor.authorOtlu, Baris
dc.contributor.authorAslan, Deniz
dc.contributor.authorEce, Cem
dc.date.accessioned2024-08-04T20:44:27Z
dc.date.available2024-08-04T20:44:27Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Klebsiella pneumoniae is an important nosocomial pathogen that can lead to high morbidity and mortality. ESBL and carbapenamase producing strains may cause epidemic situations. The aim of our study was to investigate the molecular epidemiology and clonal relationship between carbapenem resistant K. pneumoniae strains isolated from our hospital during a three month period. Methods: Fourteen carbapenem resistant K. pneumoniae strains isolated during April 1st-June 30th 2013 were included. The identification and the antibiotic susceptibility of the strains were studied by Vitek 2 Compact (Biomerieux, France) system. The carbapenemase production of the isolates were investigated by Modified Hodge assay. The bla(OXA) of the strains was investigated by in house PCR. The clonal relationship between the isolates were studied by pulsed-field gel electrophoresis (PFGE) and automatized repetitive extragenic palindromic PCR (Rep-PCR, DiversiLab sistemi, Biomerieux, France) methods. Results: All the K. pneumoniae isolates were carbapenem resistant; they were all susceptible to gentamycin and colistin. All of them had bla(OXA-48). The genotyping analysis revealed that eight isolates were in the same cluster both by Rep-PCR (similarity border >= 95%) and PFGE (Tennover criteriae) analysis. The other isolates did not belong to any other clusters. The strains that are in the same cluster are isolated from the Anesthesiology Intensive Care Unit during a three month period. The cluster ration by both methods was 57%. Conclusions: All K. pneumoniae strains possessed bla(OXA-48). The clonal spreading was particularly detected in Anesthesiology Intensive Care Unit. Molecular epidemiological monitorization of nosocomial pathogens may prevent the spread of these multidrug resistant pathogens. (C) 2018 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences.en_US
dc.identifier.doi10.1016/j.jiph.2018.04.003
dc.identifier.endpage642en_US
dc.identifier.issn1876-0341
dc.identifier.issn1876-035X
dc.identifier.issue5en_US
dc.identifier.pmid29709574en_US
dc.identifier.scopus2-s2.0-85046154875en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage640en_US
dc.identifier.urihttps://doi.org/10.1016/j.jiph.2018.04.003
dc.identifier.urihttps://hdl.handle.net/11616/98261
dc.identifier.volume11en_US
dc.identifier.wosWOS:000442781000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Londonen_US
dc.relation.ispartofJournal of Infection and Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbapenem resistant K. pneumoniaeen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectbla(OXA-48)en_US
dc.titleDetection of blaOXA-48 and clonal relationship in carbapenem resistant K-pneumoniae isolates at a tertiary care center in Western Turkeyen_US
dc.typeArticleen_US

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