Side effects of tamoxifen in oophorectomized rats

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dc.contributor.authorKafkasli, A
dc.contributor.authorErdem, F
dc.contributor.authorMüezzinoglu, B
dc.contributor.authorAkbasak, B
dc.contributor.authorBurak, F
dc.contributor.authorAksoy, T
dc.contributor.authorBirincioglu, M
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Our objective was to evaluate the direct effect of tamoxifen citrate (TAM) on the endometrium, liver, breast tissue and the lipid profile in oophorectomized (OX) rats. Study Design: An experimental animal study. Material and Methods: Forty-one mature rats (33 OX) were randomly divided into four groups and received either TAM (0.4 or 0.8 mg/kg p.o.) therapy or placebo over 60 days as follows: (1) sham; (2) OX + TAM (0.4 mg/kg); (3) OX + TAM (0.8 mg/kg); (4) OX. All histological changes in the endometrium, liver and breast tissue were evaluated under the light microscope by comparing the TAM-treated groups with the OX and sham-operated groups. Blood total cholesterol and low-density lipoprotein cholesterol levels were also analyzed. Results: TAM-treated rats showed a significant reduction in body weight, blood cholesterol and low-density lipoprotein cholesterol levels, but the wet uterine weight was not affected. Estrogenic effects of TAM were not detected with either dosage on the endometrium. TAM-treated groups showed atrophic breast tissue. No histopathological changes were detected in the liver with TAM treatment. Conclusion: The data suggests that TAM may not act as an estrogen receptor agonist with the given dosage on the endometrium in OX rats. Two different doses of TAM do not cause histological changes in liver over 60 days of treatment.en_US
dc.identifier.endpage98en_US
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue2en_US
dc.identifier.pmid9517800en_US
dc.identifier.scopus2-s2.0-0031907609en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://hdl.handle.net/11616/93119
dc.identifier.volume45en_US
dc.identifier.wosWOS:000072240600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttamoxifenen_US
dc.subjectendometrial canceren_US
dc.subjectliver canceren_US
dc.titleSide effects of tamoxifen in oophorectomized ratsen_US
dc.typeArticleen_US

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