Preparation and evaluation of furosemide containing orally disintegrating tablets by direct compression

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dc.authoridOzturk, Naile/0000-0002-7617-8433
dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authoridVural, Imran/0000-0002-1627-3834
dc.authorwosidOzturk, Naile/F-3650-2017
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.authorwosidGULSUN, TUGBA/J-1050-2013
dc.contributor.authorGulsun, T.
dc.contributor.authorOzturk, N.
dc.contributor.authorKaynak, M. S.
dc.contributor.authorVural, I.
dc.contributor.authorSahin, S.
dc.date.accessioned2024-08-04T20:43:13Z
dc.date.available2024-08-04T20:43:13Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this research was to develop and prepare orally disintegrating tablets (ODTs) containing furosemide by direct compression method. Furosemide, microcrystalline cellulose (MCC), low-substituted hydroxypropylcellulose LH-11 (L-HPC), aspartame, sodium stearyl fumarate were used for ODT formulation. MCC and L-HPC were used in ratios of 1:9 (ODT1) and 1:4 (ODT2). The results of the quality control parameters obtained for bulk powders (angle of repose, compressibility index, Hausner ratio, bulk density and volume, apparent density and volume, swelling of superdisintegrants and powder moisture) were taken as an indication of good compressibility of tablets. Both ODT1 and ODT2 disintegrated within 15 s and fulfilled the required disintegration time given by the European Pharmacopoeia (3 min). The average weight variation was less than 5% for both tablets. The friability of the tablets was less than 1%. Wetting time of both tablets was in the range of 12-21.7 s. Water absorption ratio was 1.41 +/- 0.03 for ODT1 and 1.96 +/- 0.10 for ODT2. Dissolution studies revealed that more than 85% of furosemide was dissolved in 15 min from both ODTs. Based on cell culture studies, permeability of furosemide was low (Papp=1x10-(5) cm/s) but increased when prepared in the ODT form (ODT1: Papp=2x10-(5) cm/s; ODT2: Papp=3.6x10-(5) cm/s). Collectively, all these results showed that ODT formulations of furosemide were developed successfully. To improve patient compliance, ODT approach can be suggested for development and manufacturing of furosemide ODTs.en_US
dc.identifier.doi10.1691/ph.2017.6149
dc.identifier.endpage394en_US
dc.identifier.issn0031-7144
dc.identifier.issue7en_US
dc.identifier.pmid29441935en_US
dc.identifier.scopus2-s2.0-85021662696en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://doi.org/10.1691/ph.2017.6149
dc.identifier.urihttps://hdl.handle.net/11616/97872
dc.identifier.volume72en_US
dc.identifier.wosWOS:000408295400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGovi-Verlag Pharmazeutischer Verlag Gmbhen_US
dc.relation.ispartofPharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTaste-Maskingen_US
dc.subjectDosage Formen_US
dc.subjectFormulationen_US
dc.subjectPermeabilityen_US
dc.subjectGranulesen_US
dc.subjectReleaseen_US
dc.subjectPharmacokineticsen_US
dc.subjectExcipientsen_US
dc.subjectCelluloseen_US
dc.subjectDesignen_US
dc.titlePreparation and evaluation of furosemide containing orally disintegrating tablets by direct compressionen_US
dc.typeArticleen_US

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