Synthesis of cobalt selenide composite material: A novel platform of the electrochemical sensor for sensitive determination of Upadacitinib

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dc.authoridBouali, Wiem/0009-0004-5096-6804;
dc.authorwosidBouali, Wiem/JGC-9825-2023
dc.authorwosidGENC, Asena Ayse/KOD-4330-2024
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorBouali, Wiem
dc.contributor.authorBugday, Nesrin
dc.contributor.authorYasar, Sedat
dc.contributor.authorErk, Nevin
dc.date.accessioned2024-08-04T20:55:54Z
dc.date.available2024-08-04T20:55:54Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study investigates the first electrochemical determination of Upadacitinib (UPA), a potent Janus kinase (JAK) inhibitor with remarkable efficacy in treating various inflammatory disorders, utilizing a GCE modified with a composite material comprising Co6.8Se8 embedded in porous carbon (Co6.8Se8@NPC). Simultaneously, a novel Co6.8Se8@NPC composite was synthesized using a zeolitic imidazolate framework (ZIF-12) via a one -pot synthesis method. The characterizations confirmed that Co6.8Se8@NPC is uniformly dispersed within the porous carbon network. Leveraging the applications of Metal -Organic Frameworks (MOFs) and their derivatives, Co6.8Se8@NPC was explored for the determination of UPA. The electrochemical behavior of UPA was systematically investigated using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy, upon modifying the GCE with the Co6.8Se8@NPC composite. These materials significantly enhanced sensitivity and selectivity for Upadacitinib detection. Compared with the unmodified electrode, the Co6.8Se8@NPC/GCE exhibited a notable catalytic effect towards the oxidation of UPA, as evidenced by the appearance of an irreversible oxidative peak at a reduced potential and an enhancement in current. The developed method exhibited exceptional performance characteristics with a broad linear range, and low limits of detection and quantification. Moreover, the sensor exhibits good selectivity, repeatability, and stability. Furthermore, the investigation extended to the determination of Upadacitinib in pharmaceutical and biological samples, underscoring the practical applicability of the modified GCE in real -world scenarios.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Ankara University [TSA-2023- 2738]; Scientific Research Project Office of Ankara University [TDK-2023-3036/TDK-2023-3039/TDK-2023-3126]; BAP Unit of Inonue University [FDK- 2023-3311]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Ankara University with the project number TSA-2023- 2738, the Scientific Research Project Office of Ankara University (A.UE. BAP) (Project no: TDK-2023-3036/TDK-2023-3039/TDK-2023-3126) , and the BAP Unit of Inonue University with the project number FDK- 2023-3311.en_US
dc.identifier.doi10.1016/j.electacta.2024.144164
dc.identifier.issn0013-4686
dc.identifier.issn1873-3859
dc.identifier.scopus2-s2.0-85188998336en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.electacta.2024.144164
dc.identifier.urihttps://hdl.handle.net/11616/101908
dc.identifier.volume487en_US
dc.identifier.wosWOS:001217421100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofElectrochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectJanus kinase (JAK) inhibitoren_US
dc.subjectUpadacitiniben_US
dc.subjectCo6.8Se8@NPC compositeen_US
dc.subjectElectrochemical sensoren_US
dc.subjectPharmaceutical analysisen_US
dc.titleSynthesis of cobalt selenide composite material: A novel platform of the electrochemical sensor for sensitive determination of Upadacitiniben_US
dc.typeArticleen_US

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