Gentamicin-induced nephrotoxicity and protective effect of caffeic acid phenethyl ester in rats

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorVardi, N
dc.contributor.authorParlakpinar, H
dc.contributor.authorOzturk, F
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:13:50Z
dc.date.available2024-08-04T20:13:50Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to investigate the beneficial effects of caffeic acid phenethyl ester (CAPE) on gentamicin (GM)-induced nephrotoxicity in Wistar rats. Twenty-one adult Wistar rats were divided into three groups as follows: control group, GM and GM + CAPE group. Control group rats were injected with 5% ethanol, GM group rats were treated with 100 mg/kg GM and GM + CAPE group were pretreated with 10 mu mol/kg CAPE for 2 days, then exposed to GM at the same dose. Drug injections were applied for 12 days. Twenty-four hours after the last injection, rats were killed and kidneys were quicky removed. Tissue malondialdehyde (MDA) measurements and microscopic examination of kidneys were performed. In the GM group, significant increases in MDA levels were observed (P < 0.05). These changes were found to be normalized in the GM + CAPE group. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules were found to be prevented by CAPE pretreatment. In conclusion, CAPE exerted an improvement on GM-induced nephrotoxicity, possibly, at least in part through inhibition of the production of oxygen free radicals that cause lipid peroxidation.en_US
dc.identifier.doi10.1111/j.1472-8206.2005.00321.x
dc.identifier.endpage177en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue2en_US
dc.identifier.pmid15810897en_US
dc.identifier.scopus2-s2.0-17144386934en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1111/j.1472-8206.2005.00321.x
dc.identifier.urihttps://hdl.handle.net/11616/93876
dc.identifier.volume19en_US
dc.identifier.wosWOS:000227864500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgentamicinen_US
dc.subjectlight microscopyen_US
dc.subjectnephrotoxicityen_US
dc.subjectreactive oxygen speciesen_US
dc.titleGentamicin-induced nephrotoxicity and protective effect of caffeic acid phenethyl ester in ratsen_US
dc.typeArticleen_US

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