Melatonin improves methanol intoxication-induced oxidative liver injury in rats

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dc.authorscopusid6507390425
dc.authorscopusid16833988900
dc.authorscopusid6602939148
dc.authorscopusid6701336286
dc.authorscopusid14051626400
dc.authorscopusid13005751000
dc.authorscopusid6603585456
dc.contributor.authorKurcer Z.
dc.contributor.authorO?uz E.
dc.contributor.authorIraz M.
dc.contributor.authorFadillioglu E.
dc.contributor.authorBaba F.
dc.contributor.authorKoksal M.
dc.contributor.authorOlmez E.
dc.date.accessioned2024-08-04T19:59:31Z
dc.date.available2024-08-04T19:59:31Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was performed to evaluate the effect of melatonin on methanol-induced liver injury. We evaluated the levels of malondialdehyde (MDA), protein carbonylation (PC), myeloperoxidase (MPO) activities and to assess lipid peroxidation, protein oxidation, neutrophil accumulation and nitrite which is a stable end product of nitric oxide respectively. We also studied superoxide dismutase, catalase, and glutathione peroxidase activities of liver tissue to evaluate the changes in the antioxidant status. Histopathological alterations were also determined. The experiment was performed on Wistar rats, which received intragastric 3 g/kg methanol as a 50% solution in isotonic saline once. After 6 and 24 hr all the drug received and intoxicated rats were killed under anesthesia. Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities. Additionally in melatonin treated group piecemeal necrosis, lobular lytic necrosis, and portal inflammation returned to normal histologic appearances when compared with methanol administration. In conclusion, melatonin has protective effects against methanol-induced hepatic injury. © 2007 The Authors.en_US
dc.identifier.doi10.1111/j.1600-079X.2007.00441.x
dc.identifier.endpage49en_US
dc.identifier.issn0742-3098
dc.identifier.issue1en_US
dc.identifier.pmid17614834en_US
dc.identifier.scopus2-s2.0-34447135001en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2007.00441.x
dc.identifier.urihttps://hdl.handle.net/11616/90696
dc.identifier.volume43en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntoxicationen_US
dc.subjectLiveren_US
dc.subjectMelatoninen_US
dc.subjectMethanolen_US
dc.subjectRaten_US
dc.titleMelatonin improves methanol intoxication-induced oxidative liver injury in ratsen_US
dc.typeArticleen_US

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