Predictive Value of Pretransplant Cytomegalovirus-Specific Cellular Immunity for Posttransplant CMV Infection in Liver Transplant Recipients Under Antiviral Prophylaxis

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dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorBayindir, Yasar
dc.contributor.authorAkbulut, Sami
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorIsik, Burak
dc.date.accessioned2026-04-04T13:34:45Z
dc.date.available2026-04-04T13:34:45Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground Existing data suggest that cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) in solid organ recipients may predict post-transplant CMV infection, but the available information is still limited, and needs to be validated for larger patient populations under certain circumstances. This study aimed to determine whether CMV-CMI could predict post-transplant CMV infection in liver transplant recipients (LTRs) receiving antiviral prophylaxis (AVP). Methods A total of 1769 LTRs at the Inonu University Liver Transplantation Institute were retrospectively analyzed. CMV-CMI in a total of 334 patients (> 91% were CMV donor [D] positive/recipient [R] positive) who received AVP were analyzed using the CMV-Interferon (CMV-QF; QuantiFERON-CMV, Qiagen, Germany) assay within the week before transplantation. Patients were divided into two groups: group 1 (positive; n = 171, 51.2%) and group 2 (negative; n = 163, 48.8%). Patient variables were analyzed statistically. Results A total of 124 LTRs developed CMV infection. Patients' pre-transplant characteristics did not differ significantly by their CMV-CMI result. A significantly lower percentage of LTRs with CMV-CMI positive developed infection than those with negatives (7.6% vs 68.1%, P < .001). All CMV-CMI positive patients fully recovered with antiviral treatment but only 76.6% of LTRs with negative CMV-CMI (P = .032). Logistic regression analysis showed that a negative CMV-CMI was associated with a 26 times increased risk of CMV infection compared to those with positive CMV-CMI (odds ratio [OR] = 25.9, P < .001). Female recipients developed CMV infection earlier after cessation of AVP than male recipients (median = 128 vs 144 days, P = .038). Conclusions The pre-transplant status of CMV-CMI may be a strong indicator of post-transplant CMV infection for LTRs receiving AVP. Therefore, further consideration should be made for the LTRs with negative CMV-CMI.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TSA-2016/66]
dc.description.sponsorshipThis study was supported and funded by the Inonu University Scientific Research Projects Coordination Unit (Project No: TSA-2016/66) .
dc.identifier.doi10.1016/j.transproceed.2025.07.006
dc.identifier.endpage1609
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue8
dc.identifier.orcid0000-0002-2395-3985
dc.identifier.orcid0000-0002-2915-4666
dc.identifier.orcid0000-0002-0449-0356
dc.identifier.orcid0000-0003-1208-4072
dc.identifier.orcid0000-0002-6220-0521
dc.identifier.orcid0000-0003-3930-774X
dc.identifier.orcid0000-0002-6864-7711
dc.identifier.pmid40803943
dc.identifier.scopus2-s2.0-105013096583
dc.identifier.scopusqualityQ3
dc.identifier.startpage1603
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2025.07.006
dc.identifier.urihttps://hdl.handle.net/11616/109391
dc.identifier.volume57
dc.identifier.wosWOS:001598179200010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.titlePredictive Value of Pretransplant Cytomegalovirus-Specific Cellular Immunity for Posttransplant CMV Infection in Liver Transplant Recipients Under Antiviral Prophylaxis
dc.typeArticle

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