European Liver Transplant Registry: Donor and transplant surgery aspects of 16,641 liver transplantations in children

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dc.authoridColledan, Michele/0000-0002-3880-4763
dc.authoridde Ville de Goyet, Jean/0000-0001-7681-6178
dc.authoridKalicinski, Piotr/0000-0003-0555-2229
dc.authoridPolak, Wojciech/0000-0002-3096-4893
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridVerkade, Henkjan J/0000-0002-7034-2861
dc.authoridde Kleine, Ruben/0000-0003-3975-3184
dc.authorwosidKaram, Vincent/HLQ-6211-2023
dc.authorwosidDi Francesco, Fabio/I-8756-2012
dc.authorwosidColledan, Michele/JGM-6908-2023
dc.authorwosidde Ville de Goyet, Jean/I-6913-2019
dc.authorwosidKalicinski, Piotr/AEN-1920-2022
dc.authorwosidPolak, Wojciech/AAM-6937-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorde Goyet, Jean de Ville
dc.contributor.authorBaumann, Ulrich
dc.contributor.authorKaram, Vincent
dc.contributor.authorAdam, Rene
dc.contributor.authorNadalin, Silvio
dc.contributor.authorHeaton, Nigel
dc.contributor.authorReding, Raymond
dc.date.accessioned2024-08-04T20:50:42Z
dc.date.available2024-08-04T20:50:42Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims The European Liver Transplant Registry (ELTR) has collected data on liver transplant procedures performed in Europe since 1968. Approach and Results Over a 50-year period (1968-2017), clinical and laboratory data were collected from 133 transplant centers and analyzed retrospectively (16,641 liver transplants in 14,515 children). Data were analyzed according to three successive periods (A, before 2000; B, 2000-2009; and C, since 2010), studying donor and graft characteristics and graft outcome. The use of living donors steadily increased from A to C (A, n = 296 [7%]; B, n = 1131 [23%]; and C, n = 1985 [39%]; p = 0.0001). Overall, the 5-year graft survival rate has improved from 65% in group A to 75% in group B (p < 0.0001) and to 79% in group C (B versus C, p < 0.0001). Graft half-life was 31 years, overall; it was 41 years for children who survived the first year after transplant. The late annual graft loss rate in teenagers is higher than that in children aged Pediatric liver transplantation has reached a high efficacy as a cure or treatment for severe liver disease in infants and children. Grafts that survived the first year had a half-life similar to standard human half-life. Transplantation before or after puberty may be the pivot-point for lower long-term outcome in children. Further studies are necessary to revisit some old concepts regarding transplant benefit (survival time) for small children, the role of recipient pathophysiology versus graft aging, and risk at transition to adult age.en_US
dc.identifier.doi10.1002/hep.32223
dc.identifier.endpage645en_US
dc.identifier.issn0270-9139
dc.identifier.issn1527-3350
dc.identifier.issue3en_US
dc.identifier.pmid34724224en_US
dc.identifier.scopus2-s2.0-85115724967en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage634en_US
dc.identifier.urihttps://doi.org/10.1002/hep.32223
dc.identifier.urihttps://hdl.handle.net/11616/100219
dc.identifier.volume75en_US
dc.identifier.wosWOS:000730929100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofHepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRecipientsen_US
dc.subjectSurvivalen_US
dc.subjectComplicationsen_US
dc.titleEuropean Liver Transplant Registry: Donor and transplant surgery aspects of 16,641 liver transplantations in childrenen_US
dc.typeArticleen_US

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