Is eribulin treatment prognostic factor in patients with metastatic breast cancer treated with this drug? Retrospective analysis of a multicentre study

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dc.authoridAytekin, Aydın/0000-0002-7001-3945
dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authoridElkıran, Emin Tamer/0000-0001-6681-7249
dc.authoridKaplan, Muhammet Ali/0000-0003-0882-0524
dc.authorwosidDOGAN, MUTLU/GNP-7311-2022
dc.authorwosidAytekin, Aydın/AAL-7959-2020
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidGeredeli, Caglayan/AAN-4122-2020
dc.authorwosidturan, nedim/GXG-8035-2022
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidÖZASLAN, ERSİN/V-3556-2017
dc.contributor.authorOruc, Zeynep
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorGeredeli, Caglayan
dc.contributor.authorSari, Nilgun Yildirim
dc.contributor.authorOzaslan, Ersin
dc.contributor.authorAytekin, Aydin
dc.contributor.authorElkiran, Emin Tamer
dc.date.accessioned2024-08-04T20:47:17Z
dc.date.available2024-08-04T20:47:17Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: This study aimed to analyze prognostic factors for survival and the reliability and the effectiveness of eribulin therapy in metastatic breast cancer (MBC) patients. Methods: A total of 80 patients treated with eribulin in 12 medical oncology centers in Turkey between 2013-2017 were retrospectively evaluated. Sixteen potential prognostic variables were assessed for analysis. Results: The patients had received a median of 5 prior chemotherapy regimens and a median of 3 eribulin cycles for MBC. Median progression-free survival (PFS) was 5.5 months (95% Cl: 4.1-7.8) and median overall survival (OS) was 11 months (95 % Cl: 6-15). Multivariate analysis showed that eribulin treatment line was shown to have independent prognostic significance for PFS. PFS difference was demostrated in patients who received 3 chemotherapy lines for advanced disease compared to those who had more than 3 chemotherapy lines [median PFS; 3 lines: 8.6 months (6.2-11) and >3 lines: 4.6 months (3.7-4.6) p=0.00]. The clinical benefit rate (CBR) was 52.5 and 35% in patients treated with three lines and with >3 previous chemotherapeutic regimens. Most common toxicities were neutropenia (62.5%), fatigue (52.5%), alopecia (50%) and nausea (37.5%). Conclusions: Eribulin treatment line was identified as indepedent prognostic factor for PFS in MBC patients.en_US
dc.identifier.endpage1883en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue5en_US
dc.identifier.pmid31786850en_US
dc.identifier.scopus2-s2.0-85084634447en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1876en_US
dc.identifier.urihttps://hdl.handle.net/11616/99281
dc.identifier.volume24en_US
dc.identifier.wosWOS:000501762000018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmetastatic breast canceren_US
dc.subjecteribulinen_US
dc.subjectchemotherapyen_US
dc.subjectprognostic factorsen_US
dc.subjectbreast canceren_US
dc.titleIs eribulin treatment prognostic factor in patients with metastatic breast cancer treated with this drug? Retrospective analysis of a multicentre studyen_US
dc.typeArticleen_US

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