Demodex parasite density in patients with melasma: a case-control study

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dc.contributor.authorBaran, Fatma Bengisu
dc.contributor.authorAltunisik, Nihal
dc.contributor.authorTurkmen, Dursun
dc.contributor.authorKanat, Zekiye
dc.contributor.authorSener, Serpil
dc.date.accessioned2026-04-04T13:33:32Z
dc.date.available2026-04-04T13:33:32Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Although multiple factors contribute to the development of melasma, there are reports suggesting a potential role of Demodex parasites in hyperpigmentation. This study aimed to compare the density and prevalence of Demodex infestation between patients with melasma and healthy controls. Methods: This case-control study included 35 melasma patients and 35 healthy volunteers. Standard superficial skin biopsies using cyanoacrylate adhesive were taken from the malar regions. Samples were examined via light microscopy, with a density of >= 5 Demodex/cm(2) defined as positive. Results: No statistically significant difference was found between the melasma and control groups in terms of Demodex mite density or positivity rates. Correlation analysis revealed no significant relationship between mMASI scores and Demodex mite density. As a secondary finding, the mean mMASI score was significantly higher in male participants compared to female participants. Conclusion: In this case-control study, we found no statistically significant association between Demodex parasite density and melasma in our study population. While our findings do not support an association in this sample, future large-scale and multicenter studies could further explore the potential role of Demodex in skin disorders that have been suggested by other reports. The single-center design and moderate sample size should be considered when interpreting these results.
dc.identifier.doi10.1080/15569527.2026.2639710
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.orcid0000-0003-0263-4587
dc.identifier.pmid41778367
dc.identifier.scopus2-s2.0-105032157160
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/15569527.2026.2639710
dc.identifier.urihttps://hdl.handle.net/11616/109221
dc.identifier.wosWOS:001707243500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectMelasma
dc.subjectdemodex mite
dc.subjectpigmented demodicosis
dc.subjecthyperpigmentation
dc.subjectdermoscopy
dc.titleDemodex parasite density in patients with melasma: a case-control study
dc.typeArticle

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