The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

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dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridParlak, Gozde/0000-0002-8982-887X
dc.authoridBEYAZ, SEDA/0000-0003-0436-8112
dc.authoridBeyaz, Seda/0000-0003-0436-8112
dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidParlak, Gozde/ISA-6808-2023
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidBEYAZ, SEDA/ABI-5835-2020
dc.authorwosidCan, Muhammed İsmail/ABG-8646-2020
dc.authorwosidBeyaz, Seda/ABD-1252-2021
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.contributor.authorAslan, Abdullah
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorGok, Ozlem
dc.contributor.authorBeyaz, Seda
dc.contributor.authorParlak, Gozde
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.date.accessioned2024-08-04T20:50:41Z
dc.date.available2024-08-04T20:50:41Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, 42 Wistar albino male rats (n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control group: Standard diet; (ii) RJ (royal jelly) group: Standard diet + royal jelly; (iii) F50 group: Standard diet + 50 mg/kg fluoride; (iv): F100 group: Standard diet + 100 mg/kg fluoride; (v) F50+RJ group: Standard diet + 50 mg/kg fluoride + royal jelly; (vi): F100+RJ group: Standard diet + 100 mg/kg fluoride + royal jelly. After 8 weeks, the rats were decapitated, and their muscle tissues were removed. Expression levels of Caspase-3, Caspase-6, Bax, tumor necrosis factor-alpha (TNF-alpha), interleukin 1 alpha (IL1-alpha) and Bcl-2 proteins in muscle tissue were determined by western blotting method. Histopathological analyses were also performed on the muscle tissue. Malondialdehyde (MDA), glutathione (GSH) and catalase (CAT) analyses were determined by a spectrophotometer. According to the obtained results, Bcl-2, TNF-alpha and IL1-alpha protein expression was increased in damage groups compared to the control and royal jelly groups, while Caspase-3, Caspase-6 and Bax protein expression levels decreased in damage groups. MDA level increased in damage groups compared to the control and royal jelly groups, while CAT and GSH levels increased with royal jelly application in royal jelly-given group in comparison to the flouride-exposed group. According to histopathological analysis results, edema and inflammatory cell formations were found in the injury groups, a tendency to decrease in these injuries was observed in the treatment groups. Based on these results, we can say that royal jelly has protective effects on muscle tissue against fluoride damage.en_US
dc.description.sponsorshipFirat University Scientific Research Coordination Unit (FUBAP) [FF.19.16]en_US
dc.description.sponsorshipThis study was supported by Firat University Scientific Research Coordination Unit (FUBAP) with the project number FF.19.16.en_US
dc.identifier.doi10.1007/s11356-021-16456-z
dc.identifier.endpage10557en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue7en_US
dc.identifier.pmid34528203en_US
dc.identifier.scopus2-s2.0-85115025198en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage10547en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-021-16456-z
dc.identifier.urihttps://hdl.handle.net/11616/100204
dc.identifier.volume29en_US
dc.identifier.wosWOS:000696153600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectFluorideen_US
dc.subjectIL1-alphaen_US
dc.subjectMuscle damageen_US
dc.subjectRoyal jellyen_US
dc.subjectTNF-alphaen_US
dc.titleThe inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in ratsen_US
dc.typeArticleen_US

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