Role of propolis on biochemical parameters in kidney and heart tissues against L-NAME induced oxidative injury in rats

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dc.authoridGulhan, Mehmet Fuat/0000-0003-4838-1597
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridCakir, Oguz/0000-0002-8006-2054
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidÇakır, Oğuz/CAF-8360-2022
dc.authorwosidGulhan, Mehmet Fuat/ABF-6804-2021
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorCiftci, Osman
dc.contributor.authorCakir, Oguz
dc.contributor.authorGulhan, Mehmet Fuat
dc.contributor.authorPasaoglu, Oguz Murat
dc.date.accessioned2024-08-04T20:39:54Z
dc.date.available2024-08-04T20:39:54Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNitric oxide (NO), produced by endothelial NO synthase, is recognised as a central antiinflammatory and antiatherogenic principle in the vasculature. Epidemiological and clinical studies have demonstrated that a growing list of natural products, as components of the daily diet or phytomedical preparations, may improve vascular function by enhancing NO bioavailability. In this article, we investigated antioxidant effects of propolis on biochemical parameters in kidney and heart tissues of acute NO synthase inhibited rats by N-omega-nitro-L-arginine methyl ester (L-NAME). There was increase (p < 0.001) in the activities of catalase and malondialdehyde levels in the L-NAME treatment groups when compared with control rats, but NO levels were decreased in both kidney and heart tissues. There were statistically significant changes (p < 0.001) in these parameters of L-NAME + propolis treated rats as compared with L-NAME-treated group. In summary, propolis may influence endothelial NO production.en_US
dc.description.sponsorshipNigde University Research Fund [BAP 2008/25]en_US
dc.description.sponsorshipThe authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. Nigde University Research Fund (BAP 2008/25) is gratefully acknowledged for support of this work.en_US
dc.identifier.doi10.3109/10641963.2013.863322
dc.identifier.endpage496en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue7en_US
dc.identifier.pmid24490594en_US
dc.identifier.scopus2-s2.0-84908280844en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage492en_US
dc.identifier.urihttps://doi.org/10.3109/10641963.2013.863322
dc.identifier.urihttps://hdl.handle.net/11616/96582
dc.identifier.volume36en_US
dc.identifier.wosWOS:000344603300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalaseen_US
dc.subjectL-NAMEen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectpropolisen_US
dc.subjectraten_US
dc.titleRole of propolis on biochemical parameters in kidney and heart tissues against L-NAME induced oxidative injury in ratsen_US
dc.typeArticleen_US

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