Remifentanil with thiopental for tracheal intubation without muscle relaxants

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dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorDurmus, M
dc.contributor.authorEnder, G
dc.contributor.authorKadir, BA
dc.contributor.authorNurcin, G
dc.contributor.authorErdogan, O
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:13:18Z
dc.date.available2024-08-04T20:13:18Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTracheal intubation may be accomplished with remifentanil and a non-opioid IV anesthetic without a muscle relaxant. In this study, we evaluated in double-blinded, prospective, randomized manner the dose requirements for remifentanil with thiopental without muscle relaxant administration to obtain clinically acceptable intubation conditions and cardiovascular responses. After premedication with midazolam 0.03 mg/kg IV, 105 patients were randomized equally to one of three study groups, each receiving the following: remifentanil 2 mug/kg (Group 1), 3 mug/kg (Group 11), and 4 mug/kg (Group Ell). Remifentanil was administered over 30 s, and anesthesia was induced with thiopental 5 mg/kg. Tracheal intubation conditions were assessed by the anesthesiologist performing the intubation as: (a) excellent, (b) satisfactory, (c) fair, and (d) unsatisfactory. There were no statistically significant differences among groups regarding to demographic data. Blood pressure and heart rate did not increase in any group after accomplishing intubation. There was a significant improvement in intubation conditions between Groups I and 11, 1 and 111, and II and III (P < 0.001). We conclude that remifentanil 4 mug/kg administered before thiopental 5 mg/kg provided excellent or satisfactory intubation conditions in 94% of patients and prevented cardiovascular responses to intubation.en_US
dc.identifier.doi10.1213/01.ANE.0000061222.81081.71
dc.identifier.endpage1339en_US
dc.identifier.issn0003-2999
dc.identifier.issue5en_US
dc.identifier.pmid12707129en_US
dc.identifier.scopus2-s2.0-0037406160en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1336en_US
dc.identifier.urihttps://doi.org/10.1213/01.ANE.0000061222.81081.71
dc.identifier.urihttps://hdl.handle.net/11616/93512
dc.identifier.volume96en_US
dc.identifier.wosWOS:000182456900017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia and Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemodynamic-Responseen_US
dc.subjectPropofolen_US
dc.subjectInductionen_US
dc.subjectAnesthesiaen_US
dc.subjectAlfentanilen_US
dc.subjectSurgeryen_US
dc.titleRemifentanil with thiopental for tracheal intubation without muscle relaxantsen_US
dc.typeArticleen_US

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