Role of exogenous melatonin on adriamycin-induced changes in the rat heart

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dc.contributor.authorAydemir, S.
dc.contributor.authorOzdemir, I.
dc.contributor.authorKart, A.
dc.date.accessioned2024-08-04T20:32:26Z
dc.date.available2024-08-04T20:32:26Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The protective effect of melatonin on adriamycin (ADM)-induced cardiotoxicity was investigated in the rat heart. Melatonin is a pineal hormone with free radical scavenging activity on oxidants; therefore it may decrease the ADM-induced oxidative stress and cardiotoxicity so that therapeutic efficacy might be enhanced. Materials and Methods: Wistar rats in 4 groups were treated with saline (control), melatonin (MEL), adriamycin (ADM) and melatonin plus adriamycin (MEL+ADM). Results: Adriamycin given at a single dose of 15 mg/kg significantly increased lipid peroxidation products as measured by thiobarbituric acid reactive substances (TBARS). Melatonin (5 mg/kg bw) given 2 days before and 7 days after ADM treatment reduced TBARS level. Adriamycin significantly reduced superoxide dismutase activity which was elevated by melatonin treatment. Additionally, ADM significantly increased catalase enzyme activity while melatonin normalized the ADM induced alteration in activity of catalase. Conclusions: The combined use of ADM and melatonin reduces the threat of cardiomyopathy. Melatonin seems to hold promise as a therapeutic treatment and can be recommended as an adjunct in antitumor therapy as a safe and effective protection against acute ADM-induced cardiotoxicity.en_US
dc.description.sponsorshipTurkish Government Planning Commission [96121020]en_US
dc.description.sponsorshipThis work in the B. Sunar Reeder laboratory was supported by Turkish Government Planning Commission grant 96121020.en_US
dc.identifier.endpage441en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid20556922en_US
dc.identifier.scopus2-s2.0-77954627162en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://hdl.handle.net/11616/95078
dc.identifier.volume14en_US
dc.identifier.wosWOS:000278773500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdriamycinen_US
dc.subjectMelatoninen_US
dc.subjectTBARSen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectCatalaseen_US
dc.titleRole of exogenous melatonin on adriamycin-induced changes in the rat hearten_US
dc.typeArticleen_US

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