Long-Term Post-transplant Outcomes in Patients with Hepatitis D Virus Infection at a High-Volume Liver Transplant Center

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dc.contributor.authorKeser, Muhammed Furkan
dc.contributor.authorKeser, Zeynep Busra
dc.contributor.authorYurdaydin, Cihan
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorHarputluoglu, Murat
dc.date.accessioned2026-04-04T13:37:29Z
dc.date.available2026-04-04T13:37:29Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground and Aims Hepatitis D virus (HDV) infection remains a major cause of liver failure in T & uuml;rkiye, yet post-transplant outcomes and recurrence predictors are not well defined. This study aimed to evaluate long-term outcomes and risk factors for HDV recurrence following liver transplantation in a high-volume transplant center. Methods We retrospectively analyzed 182 patients who underwent liver transplantation for HDV-related liver disease between 2010 and 2024. Clinical, virological, and survival data were compared between patients with and without HDV recurrence. Kaplan-Meier survival and Cox regression analyses were performed to identify independent predictors of recurrence. Results HDV recurrence occurred in 12 patients (6.6%) during a median follow-up of 80 months. HBIG administration significantly reduced recurrence risk (HR = 0.001, p < 0.001), while post-transplant HBV recurrence was strongly associated with HDV relapse (p < 0.001). Pre-transplant hepatocellular carcinoma (HCC) showed no significant association with HDV recurrence. Overall survival did not differ significantly between recurrence and non-recurrence groups (p = 0.068). Conclusions Our results showed that HDV recurrence was infrequent and was not associated with a statistically significant difference in post-transplant survival. Post-transplant HBV recurrence and HBIG therapy were identified as the main factors influencing HDV recurrence. Another important finding was that pre-transplant hepatocellular carcinoma (HCC) was not significantly associated with HDV recurrence. These results provide valuable long-term evidence from an HDV-endemic region and may guide post-transplant management strategies.
dc.description.sponsorshipInonu University
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK).
dc.identifier.doi10.1007/s10620-025-09654-z
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.pmid41495386
dc.identifier.scopus2-s2.0-105026908512
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10620-025-09654-z
dc.identifier.urihttps://hdl.handle.net/11616/109862
dc.identifier.wosWOS:001654972900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofDigestive Diseases and Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectHepatitis D virus
dc.subjectLiver transplantation
dc.subjectHDV recurrence
dc.subjectPost-transplant survival
dc.titleLong-Term Post-transplant Outcomes in Patients with Hepatitis D Virus Infection at a High-Volume Liver Transplant Center
dc.typeArticle

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