Resveratrol reduces ischemia reperfusion injury after experimental testicular torsion

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dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorUguralp, S
dc.contributor.authorMizrak, B
dc.contributor.authorKarabulut, AB
dc.date.accessioned2024-08-04T20:14:47Z
dc.date.available2024-08-04T20:14:47Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the study was to evaluate the effects of resveratrol on testicular ischemia reperfusion injury. Forty Wistar albino rats were divided into 4 groups. Torsions (ischemia) were created by rotating the right testis 720° in a clockwise direction for 4 hours in all groups except the control group. In the torsion group after 4 hours' ischemia bilateral orchiectomy was performed. In the detorsion group, saline was injected by an intraperitoneal route, 30 min before detorsion (reperfusion). In the resveratrol group, 30 mg/kg resveratrol was injected by an intraperitoneal route, 30 min before detorsion. In the detorsion and resveratrol groups, the bilateral testes were removed after 20 hours of detorsion. In all groups, the tissue levels of malondialdehyde (MDA) and glutathione (GSH) and histological changes were determined. In rats treated with resveratrol, MDA levels (138 ± 25 nmol/mg protein) were significantly decreased compared with torsion (426 ± 178 nmol/mg protein) and detorsion (370 ± 76 nmol/mg protein) groups (p < 0.05). GSH levels (6.54 ± 0.8 ? mol/g wet tissue) were significantly increased compared with torsion (4.61 ± 0.4 ? mol/g wet tissue) and detorsion groups (5.24 ± 0.9 ? mol/g wet tissue) (p < 0.05). The mean testicular tissue injury score in the resveratrol group was significantly lower than in torsion and detorsion groups (p < 0.05). The present study demonstrates that intraperitoneal administration of resveratrol in rats may protect testis against injury associated with reperfusion.en_US
dc.identifier.doi10.1055/s-2004-830359
dc.identifier.endpage119en_US
dc.identifier.issn0939-7248
dc.identifier.issue2en_US
dc.identifier.pmid15877260en_US
dc.identifier.scopus2-s2.0-20444435491en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.1055/s-2004-830359
dc.identifier.urihttps://hdl.handle.net/11616/93969
dc.identifier.volume15en_US
dc.identifier.wosWOS:000228960400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectresveratrolen_US
dc.subjecttestisen_US
dc.subjectischemia reperfusionen_US
dc.subjecttorsionen_US
dc.subjecttreatmenten_US
dc.titleResveratrol reduces ischemia reperfusion injury after experimental testicular torsionen_US
dc.typeArticleen_US

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