The ability of various cerebroplacental ratio thresholds to predict adverse neonatal outcomes in term fetuses exhibiting late-onset fetal growth restriction

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridKahveci, Bekir/0000-0002-8729-1669
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidKahveci, Bekir/GRX-4938-2022
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorYasar, Seyma
dc.contributor.authorHatipoglu, Irem
dc.contributor.authorKahveci, Bekir
dc.contributor.authorSucu, Mete
dc.date.accessioned2024-08-04T20:49:00Z
dc.date.available2024-08-04T20:49:00Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Our primary aim was to evaluate the ability of various cerebroplacental ratio (CPR) reference values suggested by the Fetal Medicine Foundation to predict adverse neonatal outcomes in term fetuses exhibiting lateonset fetal growth restriction (LOFGR). Our secondary aim was to evaluate the effectiveness of other obstetric Doppler parameters used to assess fetal well-being in terms of predicting adverse neonatal outcomes. Methods: This was a retrospective cohort study of 317 pregnant women diagnosed with LOFGR at 37-40 weeks of gestation between January 1, 2016, and September 1, 2019. Receiver operating characteristic (ROC) curves were drawn to determine the predictive performance of CPR <1, CPR <5th or <10th percentile, and umbilical artery pulsatility (PI) >95th percentile in terms of predicting adverse neonatal outcomes. Results: Pregnant women exhibiting LOFGR who gave birth in our clinic during the study period at a mean of 38 gestational weeks (minimum 37+0; maximum 40+6 weeks); the median CPR was 1.51 [interquartile range (IQR) 1.12-1.95] and median birthweight 2,350 g (IQR 2,125-2,575 g). The CPR <5th percentile best predicted adverse neonatal outcomes [area under the curve (AUC) 0.762, 95% confidence interval (CI) 0.672-0.853, p<0.0001] and CPR <1 was the worst predictor (AUC 0.630, 95% CI 0.515-0.745, p=0.021). Of other Doppler parameters, neither the umbilical artery systole/diastole ratio nor the mid-cerebral artery to peak systolic velocity ratio (MCA-PSV) predicted adverse neonatal outcomes (AUC 0.598, 95% CI 0 .480 - 0.598, p=0.104; AUC 0.521, 95% CI 0.396-0.521, p=0.744 respectively). Conclusions: The CPR values below the 5th percentile better predicted adverse neonatal outcomes in pregnancies complicated by LOFGR than the UA PI and CPR <1 by using Fetal Medicine Foundation reference ranges.en_US
dc.identifier.doi10.1515/jpm-2020-0244
dc.identifier.endpage215en_US
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue2en_US
dc.identifier.pmid32892179en_US
dc.identifier.scopus2-s2.0-85092782622en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1515/jpm-2020-0244
dc.identifier.urihttps://hdl.handle.net/11616/99592
dc.identifier.volume49en_US
dc.identifier.wosWOS:000626592300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadverse neonatal outcomesen_US
dc.subjectcerebroplacental ratioen_US
dc.subjectDoppler ultrasonographyen_US
dc.subjectfetal growth restrictionen_US
dc.subjectpregnancyen_US
dc.titleThe ability of various cerebroplacental ratio thresholds to predict adverse neonatal outcomes in term fetuses exhibiting late-onset fetal growth restrictionen_US
dc.typeArticleen_US

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