MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease

Simple item page
dc.authoridÇakmak, Tolga/0000-0002-4981-5521
dc.authoridYaşar, Erdoğan/0000-0001-5882-3534
dc.authoridSEKERCI, Guldeniz/0000-0002-0811-4454
dc.authorwosidŞekerci, Güldeniz/IVH-2033-2023
dc.authorwosidÇakmak, Tolga/AAN-6803-2021
dc.authorwosidYaşar, Erdoğan/GOH-1219-2022
dc.contributor.authorYasar, E.
dc.contributor.authorCakmak, T.
dc.contributor.authorBayramoglu, A.
dc.contributor.authorKaraku, Y.
dc.contributor.authorTekin, S.
dc.contributor.authorSekerci, G.
dc.contributor.authorTurkoglu, C.
dc.date.accessioned2024-08-04T20:52:17Z
dc.date.available2024-08-04T20:52:17Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Atherosclerosis plays a major role in the development of coronary artery disease (CAD). It has been shown that mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c), a mitochondrial-derived peptide, has preventive effects on atherosclerosis. The aim of this study was to determine the relationship be-tween MOTS-c levels and CAD presence and se-verity using SYNTAX score (SS) in patients with stable angina pectoris. PATIENTS AND METHODS: Ninety-two consecutive patients with stable coronary artery dis-ease (CAD+) and ninety-two consecutive patients with normal coronary artery (CAD-) were included. Presence and severity of coronary artery disease were determined using the SS. RESULTS: We observed that the MOTS-c levels was lower in the CAD group (111 +/- 13 vs. 161 +/- 23, p < 0.001). The MOTS-c levels were also found to be significant independent predictors for CAD in multiple regression analysis (p < 0.001). A MOTS-c levels & GE;130.9 had 80.3% sensitivity and 73.2% specificity (area under the curve [AUC]: 0.858, 95% CI: 0.895-0.999, p < 0.001) for predicting CAD. CONCLUSIONS: The authors revealed that there is a strong correlation between MOTS-c levels and CAD. Therefore, MOTS-c may help identify patients with CAD, thus allowing for early preventive treatment.en_US
dc.identifier.endpage5682en_US
dc.identifier.issn1128-3602
dc.identifier.issue16en_US
dc.identifier.pmid36066139en_US
dc.identifier.scopus2-s2.0-85137218220en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5676en_US
dc.identifier.urihttps://hdl.handle.net/11616/100871
dc.identifier.volume26en_US
dc.identifier.wosWOS:000877558000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectMOTS -cen_US
dc.subjectSYNTAX scoreen_US
dc.titleMOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery diseaseen_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize