Protective Effect of Curcumin Against the Toxic Effect of Acrylamide on the Rat Hippocampus

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dc.contributor.authorCetin, Seda
dc.contributor.authorOzbag, Davut
dc.contributor.authorOgeturk, Murat
dc.contributor.authorDogan, Zumrut
dc.contributor.authorAnnac, Ebru
dc.contributor.authorDumlupinar, Ebru
dc.contributor.authorErdemli, Mehmet Erman
dc.date.accessioned2026-04-04T13:35:16Z
dc.date.available2026-04-04T13:35:16Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackgroundThis study aimed to investigate the neurotoxic effects of acrylamide (AA) on the hippocampus and the potential protective effects of curcumin (CUR), a potent antioxidant, to attenuate these effects. Despite the lack of information in the literature regarding the volumetric effects of AA on the hippocampus, our study aimed to clarify this issue through stereological measurements, alongside histological and biochemical analyses.MethodsSprague-Dawley rats (similar to 250 g) were allocated into four groups: Control, AA, CUR, and AA + CUR. Both AA (50 mg/kg, intraperitoneally) and CUR (300 mg/kg, orally via gavage) were administered daily for 12 consecutive days. Following the treatment period, tissue samples were collected. Stereological, histological, and biochemical analyses were performed on the hippocampal tissue.ResultComparison of AA experimental groups data and control group data revealed that while the malondialdehyde (MDA) levels in the hippocampus increased significantly, Brain-derived neurotrophic factor (BDNF) and Glutathione (GSH) levels decreased. The results showed that CUR was effective on these levels. Histopathologically, neurons exhibited degeneration and hemorrhagic damages. According to the Cavalieri calculation, a stereological method applied to the experimental groups, no significant variation was found between the groups.ConclusionsWe determined that CUR minimizes the possible toxic effects of AA on the rat hippocampus. When the hippocampus areas were examined stereologically, we determined that it wasn't affected from this relation. We think that this was due to the short duration of our study.
dc.description.sponsorshipAdiyaman University; Inonu University Scientific Research Projects Unit
dc.description.sponsorshipWe would like to thank Inonu University Scientific Research Projects Unit for supporting our work.
dc.identifier.doi10.1007/s44411-025-00171-z
dc.identifier.endpage1672
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8
dc.identifier.orcid0000-0003-1952-4587
dc.identifier.orcid0000-0002-5744-4812
dc.identifier.orcid0000-0001-7131-2317
dc.identifier.scopus2-s2.0-105004454844
dc.identifier.scopusqualityQ2
dc.identifier.startpage1664
dc.identifier.urihttps://doi.org/10.1007/s44411-025-00171-z
dc.identifier.urihttps://hdl.handle.net/11616/109728
dc.identifier.volume126
dc.identifier.wosWOS:001483834700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAcrylamide
dc.subjectCurcumin
dc.subjectHippocampus
dc.subjectStereology
dc.subjectHistopathology
dc.subjectBiochemistry
dc.titleProtective Effect of Curcumin Against the Toxic Effect of Acrylamide on the Rat Hippocampus
dc.typeArticle

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