pH-effect on sinterability, mechanical properties and cytotoxicity of hydroxyapatite-based bone grafts

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dc.authorscopusid53863262700
dc.authorscopusid6603850717
dc.authorscopusid55781727200
dc.contributor.authorDemirel M.
dc.contributor.authorAksakal B.
dc.contributor.authorBasak N.
dc.date.accessioned2024-08-04T20:02:33Z
dc.date.available2024-08-04T20:02:33Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.descriptionInformation Engineering Research Institute, USA;Trans Tech Publications inc.en_US
dc.description2013 2nd International Conference on Chemical, Mechanical and Materials Engineering, CMME 2013 -- 20 January 2013 through 21 January 2013 -- Melbourne, VIC -- 97629en_US
dc.description.abstractHydroxyapatite (HA) based bone grafts were synthesized by sol-gel method at various pH values 5, 7, 9 and 12, respectively. In order to ascertain the influence of the obtained bone grafts on the morphology, sinterability and mechanical properties, each composition was sintered at 11500C, and quantitative phase analysis was characterized by XRD and FTIR. The microstructures were studied via SEM-EDX and the validation of mechanical properties was evaluated by compression and Vickers hardness tests. The density of HA synthesis samples with different pH values before and after sintering were measured. Besides, the cytotoxicity analysis were conducted for all grafts having various pH values. The experimental results revealed that the density and mechanical strenght of HA based bone grafts were increased with increasing pH value. The highest hardness and strength were obtained for the samples having pH=12. Furthermore, the samples with pH=12 exhibited the best densification and properties when compared to the samples at pH of 5, 7 and 9. The cytotoxicity tests also indicated that the pH=7-12 value showed no toxicity to osteoblast cells at 0,1 and 0,3 ?M concentration, whereas HA synthesis sample at pH=5 value with 0,3 ?M concentration induced significantly and reduced cell viability. © (2013) Trans Tech Publications, Switzerland.en_US
dc.identifier.doi10.4028/www.scientific.net/AMM.319.134
dc.identifier.endpage139en_US
dc.identifier.isbn9783037856864
dc.identifier.issn1660-9336
dc.identifier.scopus2-s2.0-84879725310en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.4028/www.scientific.net/AMM.319.134
dc.identifier.urihttps://hdl.handle.net/11616/91763
dc.identifier.volume319en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofApplied Mechanics and Materialsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone graften_US
dc.subjectCytotoxicityen_US
dc.subjectHydroxyapatiteen_US
dc.subjectMechanical propertiesen_US
dc.subjectpHen_US
dc.titlepH-effect on sinterability, mechanical properties and cytotoxicity of hydroxyapatite-based bone graftsen_US
dc.typeConference Objecten_US

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