Circadian rhythm disruption as a potential contributor to BPPV: Evidence from a young rat model vestibular effects of circadian disruption

Basit Öğe Kaydı
dc.contributor.authorOtlu, Husniye Gul
dc.contributor.authorKorkmaz, Hanifi
dc.contributor.authorBulut, Nilufer Diller
dc.contributor.authorGokturk, Nurcan
dc.date.accessioned2026-04-04T13:33:04Z
dc.date.available2026-04-04T13:33:04Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractCircadian rhythm disturbances, increasingly common due to artificial lighting and modern lifestyle factors, may underlie vestibular dysfunction such as benign paroxysmal positional vertigo (BPPV), even in younger populations. This study aimed to investigate the effects of circadian rhythm disruption on balance performance and vestibular biomarkers in a young rat model. Young male Wistar rats were exposed to constant light (CL) for 4 weeks to induce circadian disruption, while control rats were maintained under a standard 12:12-hour light-dark cycle. Following the exposure, serum and cochlear tissues were analyzed for otolin-1, vitamin D3, melatonin, and electrolytes (Ca-2 (+) , Na (+) , K (+) , Cl-). Balance was evaluated using the rotarod performance test. Constant light exposed rats showed significantly elevated otolin-1 levels in both serum and cochlear tissues, along with reduced melatonin levels and impaired rotarod performance. Vitamin D3 levels were lower in the CL group, while serum electrolytes remained unchanged. Circadian rhythm disruption may impair vestibular function in young rats via melatonin related pathways or otolin-1 modulation, independent of serum electrolytes. Our results imply that circadian rhythm disruption may contribute to BPPV through pathways unrelated to aging or bone metabolism.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Malatya Turgut Ozal University [2022/22]
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Malatya Turgut Ozal University under the grant number 2022/22. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.identifier.doi10.1371/journal.pone.0339869
dc.identifier.issn1932-6203
dc.identifier.issue12
dc.identifier.orcid0000-0003-2164-393X
dc.identifier.pmid41468411
dc.identifier.scopus2-s2.0-105026428119
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0339869
dc.identifier.urihttps://hdl.handle.net/11616/108891
dc.identifier.volume20
dc.identifier.wosWOS:001660626900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectParoxysmal Positional Vertigo
dc.titleCircadian rhythm disruption as a potential contributor to BPPV: Evidence from a young rat model vestibular effects of circadian disruption
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu