The effect of indole-3-acetic acid on some metabolic enzymes in kidney of the second cross maternal mice and their offsprings

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dc.authorscopusid7102711821
dc.authorscopusid35410673000
dc.contributor.authorYilmaz H.R.
dc.contributor.authorYiiksel E.
dc.date.accessioned2024-08-04T20:01:11Z
dc.date.available2024-08-04T20:01:11Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Indole-3-acetic acid (IAA) generates reactive oxygen species (ROS) and excited oxygen intermediates- IAA causes renal dysfunction, hypoglycemia, and myotonia. The first aim of the study is to investigate the possible indirect effect of the plant growth hormone IAA on some renal enzyme activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) of second cross offsprings of the second cross maternal mice (Mus musculus) that are given IAA. The second aim was to investigate the possible direct effect of IAA on the same renal enzymes in second cross maternal mice. Method: Female mice was divided into two groups: IAA administered group and ethanol control group. Two chemicals used were applied intraperitoneally IAA was administrated to maternal mice as a 1/40 dilution of 300 mg/kg body weights in 3-day intervals. Ethanol was administrated in the controls. Spectrophotometric methods were used to determine the activities of enzymes in the kidney of the second cross-maternal mice and their offsprings. Results: In the second cross-maternal mice, the activities of LDH, MDH, and G6PD were higher in IAA administrated animals than in controls. 6PGD and HK showed decreases in IAA study group compared to control group. In the offsprings of the second cross maternal mice, the activities of G6PD, HK, and MDH enzymes were decreased, and6PGDand LDH enzymes were increased in IAA group compared to control group. Even so differences were not statistically significant. Conclusion: The results obtained suggested that metabolic enzymes studied were not affected from IAA toxicity. This may be due to low dose of IAA.en_US
dc.identifier.endpage3en_US
dc.identifier.issn1301-0883
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-60649089079en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11616/91319
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIAAen_US
dc.subjectKidneyen_US
dc.subjectMetabolic enzymesen_US
dc.subjectMus musculusen_US
dc.titleThe effect of indole-3-acetic acid on some metabolic enzymes in kidney of the second cross maternal mice and their offspringsen_US
dc.typeConference Objecten_US

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