Carbamazepine-induced sperm disorders can be associated with the altered expressions of testicular KCNJ11/miR-let-7a and spermatozoal CFTR/miR-27a

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dc.authoridkuloğlu, tuncay/0000-0001-9874-3838
dc.authoridKilincli, Ayten/0000-0003-0907-0737
dc.authoridTurk, Gaffari/0000-0001-7417-1038
dc.authorwosidkuloğlu, tuncay/W-2310-2018
dc.authorwosidTektemur, Ahmet/V-8755-2018
dc.authorwosidCetin, A.Kadri/V-8225-2018
dc.authorwosidKilincli, Ayten/ABI-3408-2020
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorEtem Onalan, Ebru
dc.contributor.authorKaya Tektemur, Nalan
dc.contributor.authorDayan Cinkara, Serap
dc.contributor.authorKilincli cetin, Ayten
dc.contributor.authorTekedereli, Ibrahim
dc.contributor.authorKuloglu, Tuncay
dc.date.accessioned2024-08-04T20:49:10Z
dc.date.available2024-08-04T20:49:10Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMale infertility is a global health problem, and the underlying molecular mechanisms are not clearly known. Ion channels and microRNAs (miRNAs), known to function in many vital functions in cells, have been shown to play a significant role in male infertility through changes in their expressions. The study aimed to evaluate the alterations of testicular and/or spermatozoal potassium voltage-gated channel subfamily J member 11 (KCNJ11), Cystic fibrosis transmembrane conductance regulator (CFTR), miR-let-7a and miR-27a expressions in carbamazepine-related male infertility. Here, we showed that carbamazepine reduced sperm motility, increased abnormal sperm morphology, and impaired hormonal balance as well as increased relative testis weight and decreased relative seminal vesicle weight. On the other hand, downregulated KCNJ11 and upregulated miR-let-7a expressions were determined in testis (p < .05). Also, downregulated KCNJ11 and upregulated CFTR and miR-27a expressions were found in spermatozoa (p < .05). Interestingly, altered testicular KCNJ11 and miR-let-7a expressions were correlated with decreased sperm motility and elevated sperm tail defect. Besides, spermatozoal CFTR and miR-27a expressions positively correlated with sperm tail defects. The results indicated a significant relationship between ion channel and/or miRNA expression alterations and impaired sperm parameters due to carbamazepine usage.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [217S731]en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 217S731en_US
dc.identifier.doi10.1111/and.13954
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue2en_US
dc.identifier.pmid33372325en_US
dc.identifier.scopus2-s2.0-85098136002en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13954
dc.identifier.urihttps://hdl.handle.net/11616/99688
dc.identifier.volume53en_US
dc.identifier.wosWOS:000603142800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcarbamazepineen_US
dc.subjectIon channelen_US
dc.subjectmale infertilityen_US
dc.subjectmicroRNAen_US
dc.titleCarbamazepine-induced sperm disorders can be associated with the altered expressions of testicular KCNJ11/miR-let-7a and spermatozoal CFTR/miR-27aen_US
dc.typeArticleen_US

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