Acrylamide applied during pregnancy causes the neurotoxic effect by lowering bdnf levels in thefetal brain

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dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAladag, M. Arif
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorDemirtas, Sezin
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2019-07-04T11:27:03Z
dc.date.available2019-07-04T11:27:03Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity. Materials and methods: Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses. Results: Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p < 0.05). Conclusion: Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect.en_US
dc.identifier.citationErdemli, ME . Aladag, MA. Altinoz, E. Demirtas, S. Turkoz, Y. Yigitcan, B . Bag, HG. (2018). Acrylamide applied during pregnancy causes the neurotoxic effect by lowering bdnf levels in thefetal brain. Cilt:67. 37-43 ss.en_US
dc.identifier.doi10.1016/j.ntt.2018.03.005en_US
dc.identifier.endpage43en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/11616/12340
dc.identifier.volume67en_US
dc.language.isoenen_US
dc.publisherPergamon-elsevıer scıence ltd, the boulevard, langford lane, kıdlıngton, oxford ox5 1gb, englanden_US
dc.relation.ispartofNeurotoxıcology and teratologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-acetylcysteıneen_US
dc.subjectneurotrophıc factoren_US
dc.subjectdıetary-tınakeen_US
dc.subjectraten_US
dc.subjectfooden_US
dc.subjectsupplementatıonen_US
dc.subjectneuroprotectıonen_US
dc.subjectneurogenesıshıppen_US
dc.subjectocampusen_US
dc.subjectcarcınogenen_US
dc.titleAcrylamide applied during pregnancy causes the neurotoxic effect by lowering bdnf levels in thefetal brainen_US
dc.typeArticleen_US

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