Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.authorwosidDoğanyiğit, Züleyha/AAW-2347-2021
dc.contributor.authorCakir, Murat
dc.contributor.authorTekin, Suat
dc.contributor.authorDoganyigit, Zuleyha
dc.contributor.authorErden, Yavuz
dc.contributor.authorSoyturk, Merve
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:45:33Z
dc.date.available2024-08-04T20:45:33Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Cannabinoid system has various physiological roles such as neurogenesis, synaptic plasticity and emotional state regulation in the body. The presence of cannabinoid type 2 receptor (CB2), a member of the cannabinoid system, was detected in different regions of the brain. CB2 receptor plays a role in neuroinflammatory and neurodegenerative processes. We aimed to determine the possible effect of CB2 agonist JWH-133 in Okadaic acid (OKA)-induced neurodegeneration model mimicking Alzheimer's Disease (AD) through tau pathology. Materials and methods: In this study, 40 Sprague Dawley male rats were divided into 4 groups (Control, Sham, OKA, OKA + JWH-133). Bilateral intracerebroventricular (icv) injection of 200 ng OKA was performed in the OKA group. In the OKA + JWH-133 group, injection of JWH-133 (0.2 mg/kg) was performed intraperitoneally for 13 days different from the group of OKA. Morris water maze test was used to evaluate the spatial memory. Levels of caspase-3, phosphorylated tau (ser396), amyloid beta (A beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) levels in brain cortex; and the hippocampus regions were examined by immunohistochemical methods. Key findings: In the OKA group, caspase-3, phosphorylated tau (ser396), A beta, IL-1 beta levels were higher in the cortex and hippocampus than in the other groups. The implementation of the JWH-133 reversed the increments in these parameters, and also prevented spatial memory impairment.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects of Bozok University [6602c-TF/17-139]en_US
dc.description.sponsorshipThis study was supported by the Department of Scientific Research Projects of Bozok University (Project no: 6602c-TF/17-139). Authors declare no conflict of interest.en_US
dc.identifier.doi10.1016/j.lfs.2018.11.058
dc.identifier.endpage33en_US
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid30500552en_US
dc.identifier.scopus2-s2.0-85057559841en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2018.11.058
dc.identifier.urihttps://hdl.handle.net/11616/98553
dc.identifier.volume217en_US
dc.identifier.wosWOS:000454622400004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectOkadaic aciden_US
dc.subjectCannabinoid type 2 receptoren_US
dc.subjectJWH-133en_US
dc.titleCannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in ratsen_US
dc.typeArticleen_US

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