Neuroprotective effect of etomidate on functional recovery in experimental spinal cord injury

dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidAltinoz, Eyup/AAM-2378-2020
dc.contributor.authorCayli, Suleyman R.
dc.contributor.authorAtes, Ozkan
dc.contributor.authorKaradag, Nese
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorYucel, Neslihan
dc.contributor.authorYologlu, Saim
dc.contributor.authorKocak, Ayhan
dc.date.accessioned2024-08-04T20:15:26Z
dc.date.available2024-08-04T20:15:26Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Primary impact to the spinal cord causes rapid oxidative stress after injury. To protect neural tissue, it is important to prevent secondary pathophysiological mechanisms. Etomidate, a strong antiexcitotoxic agent, stimulates the gamma aminobutyric acid (GABA) receptors. The purpose of this study was to investigate neurobehavioral and histological recovery and to evaluate the biochemical responses to treatment of experimental spinal cord injury (SCI) in rats with etomidate or methylprednisolone (MP) or both etomidate and MP. Material and methods: Seventy-two rats were randomly allocated into six groups: a control group (laminectomy alone), a trauma group (laminectomy + trauma), a methylprednisolone group (30 mg/kg MP), an etomidate group (2 mg/kg), a methylprednisolone, and etomidate combined treatment group (30 mg/kg MP and 2 mg/kg etomidate) and a vehicle group. Six rats from each group were killed at the 24th hour after the injury. Malondialdehyde, glutathione, nitric oxide and xanthine oxidase levels were measured. Neurological functions of the remaining rats were recorded weekly. Six weeks after injury, all of those rats were killed for histopathological assesssment. Conclusion: Etomidate treatment immediately after spinal cord injury has similar neuroprotection to MR In spite of different neuroprotection mechanisms, combined treatment with MP and etomidate does not provide extra protection. (c) 2006 ISDN. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijdevneu.2006.04.003
dc.identifier.endpage239en_US
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.issue4en_US
dc.identifier.pmid16701976en_US
dc.identifier.scopus2-s2.0-33646828525en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijdevneu.2006.04.003
dc.identifier.urihttps://hdl.handle.net/11616/94388
dc.identifier.volume24en_US
dc.identifier.wosWOS:000238704600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectetomidateen_US
dc.subjectmethylprednisoloneen_US
dc.subjectspinal cord injuryen_US
dc.subjectfunctional recoveryen_US
dc.subjectmalondialdehydeen_US
dc.subjectglutathioneen_US
dc.subjectnitric oxideen_US
dc.subjectxanthine oxidaseen_US
dc.titleNeuroprotective effect of etomidate on functional recovery in experimental spinal cord injuryen_US
dc.typeArticleen_US

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