Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridözkaya, ozan/0000-0002-0198-1221
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidözkaya, ozan/AAO-2136-2020
dc.contributor.authorKalman, S
dc.contributor.authorBuyan, N
dc.contributor.authorYürekli, M
dc.contributor.authorÖzkaya, O
dc.contributor.authorBakkaloglu, S
dc.contributor.authorSöylemezoglu, O
dc.date.accessioned2024-08-04T20:14:52Z
dc.date.available2024-08-04T20:14:52Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAdrenomedullin (AM) is a strong vasodilator peptide with proven antimitogenic and antiproliferative effects in renal mesangial cells, as well as diuretic and natriuretic actions. Its gene expression is stimulated by endotoxins (lipopolysacharides) and cytokines. Consequently, its plasma and urinary levels are known to deviate from normal levels in many renal diseases. The purpose of this study is to determine plasma and urinary AM levels in children with renal parenchymal scar (RPS) and vesicoureteral reflux (VUR). The study was carried out on 74 children with recurrent urinary tract infections, arranged in groups: 25 patients with RPS with VUR (group I), 16 patients with RPS without VUR (group II), 12 patients with VUR without RPS (group III) and 21 healthy children as the control group. Plasma and urinary AM concentrations were both determined by high performance liquid chromotography (HPLC). Plasma AM was measured as picomoles per milliliter (pM/ml) and urinary AM as pM/mg urinary creatinine. In addition, serum creatinine, creatinine clearance and fractional sodium excretion (FENa) were measured. All cases with RPS and VUR had normal blood pressure levels. The plasma AM levels were higher, although not significantly, in the control group (56.2 +/- 14.0 pM/ml) than in group I (50.6 +/- 4.2 pM/ml), group II (49.6 +/- 3.7 pM/ml) and group III (50.6 +/- 3.6 pM/ml) ( P =0.162). The urinary AM levels were higher in the control group (80.1 +/- 33.9 pM/mg) than in the three study groups (52 +/- 7.6 pM/mg, 58.6 +/- 7.5 pM/mg and 44.2 +/- 6.4 pM/mg; P =0.003, P =0.002 and P =0.002, respectively). There were no differences among the 4 groups (group I, group II, group III and the control group) in terms of FENa and creatinine clearance ( P > 0.05 and P > 0.05, respectively). The finding that diminished urinary AM levels in patients with RPS and VUR implies that AM can be a prognostic factor in the long-term follow-up of cases with these diseases.en_US
dc.identifier.doi10.1007/s00467-005-1895-8
dc.identifier.endpage1115en_US
dc.identifier.issn0931-041X
dc.identifier.issue8en_US
dc.identifier.pmid15942792en_US
dc.identifier.scopus2-s2.0-22344435693en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1111en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-005-1895-8
dc.identifier.urihttps://hdl.handle.net/11616/94010
dc.identifier.volume20en_US
dc.identifier.wosWOS:000230353300012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectrenal parencyhmal scaren_US
dc.subjectvesicoureteral refluxen_US
dc.titlePlasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral refluxen_US
dc.typeArticleen_US

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