Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis

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dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidIsik, Burak/A-6657-2018
dc.contributor.authorKaradag, Nese
dc.contributor.authorKirimlioglu, Hale
dc.contributor.authorIsik, Burak
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorKirimlioglu, Vedat
dc.date.accessioned2024-08-04T20:30:53Z
dc.date.available2024-08-04T20:30:53Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe correlation between matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14 expression on the prognostic parameters of gallbladder carcinoma (GBC) and their role in carcinogenesis were evaluated. Carcinomas of the gallbladder (n = 20) and chronic cholecystitis (n = 10) were studied for the expression of MMP-2, MMP-9, and MMP-14 by immunohistochemistry. In all of the cases, metaplastic and dysplastic epithelial alterations, and (in GBC histologic type, grade of differentiation, level of infiltration, perineural and angiolymphatic invasion, liver invasion, and lymph node involvement were noted. MMP-2, MMP-9, MMP-14 were expressed in tumor epithelium in 9 (45%), 20 (100%), and 20 (100%) of the cases, respectively. MMP stromal expression including muscle layer, vascular endothelium, fibroblasts, and lymphoid cells were detected in all cases. MMP-2 was not expressed in normal, metaplastic, and dysplastic epithelia. In contrast, MMP-9 and MMP-14 immunoreactivities were present in antral-type metaplastic areas as moderate (grade 2) and strong in dysplastic epithelia (grade 3). Only in mucinous-type GBC was the expression of the MMPs lower than in the other types. No significant correlation was detected with the grade of differentiation, level of infiltration, perineural and angiolymphatic invasion, liver invasion, or lymph node involvement. These data suggest that MMP-9 and MMP-14 overexpression may have an important role in tumorigenesis. MMP-2, MMP-9, and MMP-14 were expressed in GBC epithelium but also the expression in the stromal component may be essential for the malignant potential of GBC.en_US
dc.identifier.doi10.1097/PAI.0b013e318061b748
dc.identifier.endpage152en_US
dc.identifier.issn1062-3345
dc.identifier.issue2en_US
dc.identifier.pmid18227728en_US
dc.identifier.scopus2-s2.0-46749123168en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.1097/PAI.0b013e318061b748
dc.identifier.urihttps://hdl.handle.net/11616/94588
dc.identifier.volume16en_US
dc.identifier.wosWOS:000253788700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofApplied Immunohistochemistry & Molecular Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMMPen_US
dc.subjectgallbladderen_US
dc.subjectcanceren_US
dc.subjectmetaplasiaen_US
dc.subjectdysplasiaen_US
dc.titleExpression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesisen_US
dc.typeArticleen_US

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