The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCiftci, Osman
dc.contributor.authorEraslan, Sevil
dc.contributor.authorCetin, Asli
dc.contributor.authorBasak, Nese
dc.date.accessioned2024-08-04T20:45:21Z
dc.date.available2024-08-04T20:45:21Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (lOOmg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.en_US
dc.identifier.doi10.1590/s0102-865020180060000004
dc.identifier.endpage507en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6en_US
dc.identifier.pmid30020311en_US
dc.identifier.scopus2-s2.0-85050481505en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage499en_US
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180060000004
dc.identifier.urihttps://hdl.handle.net/11616/98397
dc.identifier.volume33en_US
dc.identifier.wosWOS:000438900400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectCurcuminen_US
dc.subjectCapsaicinen_US
dc.subjectAntioxidanten_US
dc.subjectRatsen_US
dc.titleThe therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in ratsen_US
dc.typeArticleen_US

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