Effect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbits

Basit Öğe Kaydı
dc.authoridKarakaplan, Mustafa/0000-0001-9035-0319
dc.authoridergen, emre/0000-0002-6452-2401
dc.authorwosidElmali, Nurzat/A-1017-2014
dc.authorwosidKarakaplan, Mustafa/IXN-3318-2023
dc.authorwosidergen, emre/D-4118-2017
dc.contributor.authorKarakaplan, Mustafa
dc.contributor.authorElmali, Nurzat
dc.contributor.authorMirel, Efe
dc.contributor.authorSahin, Nurhan
dc.contributor.authorErgen, Emre
dc.contributor.authorElmali, Candan
dc.date.accessioned2024-08-04T20:43:10Z
dc.date.available2024-08-04T20:43:10Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim of the present study was to evaluate the effect of microfracture and intraarticular autologous conditioned plasma (ACP) injection on cartilage regeneration in a focal full-thickness chondral defect model created in the knee joint. Methods: Full-thickness chondral defects of 3 x 6 mm(2) were surgically created in right medial femoral condyles (MFC) of New Zealand rabbits, and the rabbits were then divided into three groups according to treatment: Group 1 received only microfracture (mfx), Group 2 received mfx plus intraarticular ACP, and Group 3 received mfx; the defect was covered by the periosteum, and then, ACP was applied subperiosteally and intraarticularly. Twelve weeks after injection, the animals were sacrificed and the femoral condyles were evaluated macroscopically and histologically by hematoxylin-eosin staining. Then, histological sections were scored using the International Cartilage Repair Society (ICRS) visual histological scale. Results: Findings showed that in both mfx/ACP-treated groups, the defects were filled regularly and smoothly, the defects had a greater fill and good integration into the surrounding host tissue, and the repair matrix had more hyaline-like character. On the other hand, defects were filled with an irregular, fibrous cartilage in the mfx-treated group. Histological scores in Group 2 and Group 3 were better compared to Group 1. Conclusion: In the present study, we were able to demonstrate a beneficial effect of intraarticular administration of ACP as a coadjuvant of microfractures in order to regenerate hyaline-like cartilage in full-thickness chondral lesions in a rabbit model.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Uniten_US
dc.description.sponsorshipThis work was supported by Inonu University Scientific Research Projects Coordination Unit.en_US
dc.identifier.doi10.1186/s13018-015-0254-0
dc.identifier.issn1749-799X
dc.identifier.pmid26173978en_US
dc.identifier.scopus2-s2.0-85019202543en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13018-015-0254-0
dc.identifier.urihttps://hdl.handle.net/11616/97818
dc.identifier.volume10en_US
dc.identifier.wosWOS:000357919500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofJournal of Orthopaedic Surgery and Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicrofractureen_US
dc.subjectCartilageen_US
dc.subjectPlatelet-rich plasmaen_US
dc.subjectPeriosteumen_US
dc.titleEffect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbitsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu