Effects of dexmedetomidine and midazolam sedation on the haemodynamic response to epinephrine

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dc.authorscopusid7801413617
dc.authorscopusid55942251200
dc.authorscopusid55666804700
dc.authorscopusid7006384185
dc.authorscopusid7004486274
dc.contributor.authorErdil F.
dc.contributor.authorBut A.K.
dc.contributor.authorToprak H.I.
dc.contributor.authorÖztürk E.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T20:00:59Z
dc.date.available2024-08-04T20:00:59Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of our study is to evaluate the haemodynamic response of midazolam and dexmedetomidine sedation to local anaesthetic (LA) infiltration containing epinephrine and the analgesic effects and sedation during septoplasty operations. Methods: Dexmedetomidine (Group D; n:25) and midazolam (Group M; n:20) were given to patients as their sedation levels reached 3-4. The mean blood pressure (MBP), heart rate (HR), and visual analog scale (VAS) values were recorded preoperatively, after induction doses of sedation agents, after the infiltration of local anesthesia containing epinephrine and perioperatively. Postoperatively MBP and HR were recorded at 1, 2, 4, 6, 12, and 24 hours and the pain score of the patients was evaluated by VAS. Results: In group D, MBP after 10. minutes perioperatively, and HR after the dexmedetomidine induction, perioperatively at 20 and 30 minutes and postoperatively in the first hour were significantly lower when compared with the initial values (p<0.05). In group M, MBP after the induction and postoperatively at the 2nd hour was significantly lower when compared with the initial values, but HR was significantly increased after the induction, until the perioperative 30th minute (p<0.05). As for the evaluation of the groups: in group D, MBP till the perioperative 30th minute and postoperatively at 1, 4 and 24 hours, and HR between the end of induction and the perioperative 30th minute were significantly lower when compared with group M (p<0.05). Total diclophenac consumption was significantly lower and the time to the first analgesic requirement was also significantly longer in group D when compared with group M (p<0.05). Postoperative VAS values were significantly lower in group D when compared with group M. Conclusion: The results of our study showed that dexmedetomidine sedation could be preferred in septoplasty operations because of its beneficial effects on haemodynamic response after LA infiltration containing epinephrine and for its analgesic properties which is important in the postoperative period.en_US
dc.identifier.endpage172en_US
dc.identifier.issn1300-0578
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-79960477721en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://hdl.handle.net/11616/91141
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAnestezi Dergisien_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectEpinephrineen_US
dc.subjectHaemodynamicsen_US
dc.subjectMidazolamen_US
dc.subjectSedationen_US
dc.titleEffects of dexmedetomidine and midazolam sedation on the haemodynamic response to epinephrineen_US
dc.title.alternativeEpi?nefri?ni?n oluşturdu?u hemodi?nami?k yanita deksmedetomi?di?n ve mi?dazolam sedasyonunun etki?si?en_US
dc.typeArticleen_US

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