Serum cadmium levels are independently associated with endothelial function in hemodialysis patients

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dc.authoridGeçit, İlhan/0000-0001-7329-6971
dc.authoridAri Bakir, Elif/0000-0001-9208-7972
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authorwosidGeçit, İlhan/ABI-8258-2020
dc.authorwosidAri Bakir, Elif/HJH-3482-2023
dc.authorwosidKeles, Elif Cigdem/ABI-3897-2020
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.contributor.authorKaya, Yuksel
dc.contributor.authorAri, Elif
dc.contributor.authorDemir, Halit
dc.contributor.authorGecit, Ilhan
dc.contributor.authorBeytur, Ali
dc.contributor.authorKaspar, Cigdem
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHemodialysis (HD) patients are at risk of deficiency of essential trace elements and excess of toxic trace elements. The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, and lead) and endothelial function in HD patients. Forty-eight chronic HD patients without known atherosclerotic disease and 42 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929). The serum levels of iron, zinc, and manganese were lower, and levels of copper, magnesium, cobalt, cadmium, and lead were higher in HD patients compared to controls. Flow-mediated dilatation (FMD %) in HD patients was lower than that in the control group (7.27 +/- A 0.76 vs. 11.29 +/- A 0.82, P < 0.001). There was a significant negative correlation between FMD % and serum levels of cobalt (r = -0.313, P = 0.03) and cadmium (r = -0.524, P < 0.01). A linear regression analysis showed that serum cadmium levels were still significantly and negatively correlated with FMD % (regression coefficient = -0.526, P < 0.001). We first demonstrated that serum cadmium levels independently predict endothelial function in HD patients without known atherosclerotic disease.en_US
dc.identifier.doi10.1007/s11255-011-0055-2
dc.identifier.endpage1492en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue5en_US
dc.identifier.pmid21904850en_US
dc.identifier.scopus2-s2.0-84867862560en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1487en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-011-0055-2
dc.identifier.urihttps://hdl.handle.net/11616/95826
dc.identifier.volume44en_US
dc.identifier.wosWOS:000308957400029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCadmiumen_US
dc.subjectCobalten_US
dc.subjectEndothelial functionen_US
dc.subjectHemodialysisen_US
dc.titleSerum cadmium levels are independently associated with endothelial function in hemodialysis patientsen_US
dc.typeArticleen_US

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