Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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dc.authoriddurak, mehmet akif akif/0000-0003-0827-2708
dc.authoridOzkan, Ahmet Selim/0000-0002-4543-8853
dc.authorwosiddurak, mehmet akif akif/ABI-1169-2020
dc.authorwosidOzkan, Ahmet Selim/ABH-2918-2020
dc.contributor.authorAkbas, S.
dc.contributor.authorOzkan, A. S.
dc.contributor.authorDurak, M. A.
dc.contributor.authorYologlu, S.
dc.date.accessioned2024-08-04T20:50:24Z
dc.date.available2024-08-04T20:50:24Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. - Effective postoperative pain management after lumbar disc surgery reduces complications and improves postoperative care. The purpose of this prospective, randomized, double-blind, placebo-controlled clinical study is to evaluate the effects of IV paracetamol and ibuprofen on postoperative pain, morphine consumption and side effects of morphine in patients who underwent lumbar disc surgery. Materials and methods. - Seventy-five patients aged 18-85 years scheduled for lumbar disk surgery with a single level laminectomy included in this study. All patients received morphine with an IV patient-controlled analgesia device during the first postoperative 24 hour. The patients were divided randomly and double-blinded into three groups (control, paracetamol and ibuprofen). The demographic characteristics and procedure data, VAS score, cumulative morphine consumption, opioid-related side effects were recorded. Results. - There was no significant difference regarding to demographic characteristics, comorbidities, and durations of anesthesia and surgery. There was a significant difference between all groups regarding to total morphine consumption (P< 0.001). IV ibuprofen significantly reduced the total morphine consumption in comparison with control and paracetamol (P< 0.001). Repeated measures ANOVA showed in all periods of the study that VAS score was significantly lower in ibuprofen (P < 0.001), but not in paracetamol (P= 0.394) in comparison with control. There was no difference between groups regarding postoperative heart rate, mean arterial pressure, nausea-vomiting, pruritus and urinary retention. Conclusions. - This study showed that pain scores and morphine consumption, but not the side effects of patient-controlled analgesia during 24 hours after the lumbar disk surgery, were significantly reduced by IV ibuprofen as a supplemental analgesic when compared with controls and paracetamols. (C) 2021 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.neuchi.2021.04.019
dc.identifier.endpage539en_US
dc.identifier.issn0028-3770
dc.identifier.issn1773-0619
dc.identifier.issue6en_US
dc.identifier.pmid33989641en_US
dc.identifier.scopus2-s2.0-85109919709en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.1016/j.neuchi.2021.04.019
dc.identifier.urihttps://hdl.handle.net/11616/100037
dc.identifier.volume67en_US
dc.identifier.wosWOS:000709173800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.ispartofNeurochirurgieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesiologyen_US
dc.subjectPostoperative painen_US
dc.subjectNeurosurgeryen_US
dc.subjectSpine surgeryen_US
dc.subjectIntravenous ibuprofenen_US
dc.subjectParacetamolen_US
dc.titleEfficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trialen_US
dc.typeArticleen_US

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