Investigation of SARS-CoV-2 RNA in milk produced by women with COVID-19 and follow-up of their infants: A preliminary study

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dc.authoridKilic, Talat/0000-0001-8125-9062
dc.authoridGündüz, Ayten/0000-0003-2031-9978
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authorwosidKilic, Talat/ABI-4457-2020
dc.authorwosidGündüz, Ayten/HKO-6509-2023
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.contributor.authorKilic, Talat
dc.contributor.authorKilic, Sebnem
dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorGunduz, Ayten
dc.contributor.authorErsoy, Yasemin
dc.date.accessioned2024-08-04T20:49:29Z
dc.date.available2024-08-04T20:49:29Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives Studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily transmitted from person to person via airborne droplets. It is unclear whether it can be shed into human milk and transmitted to a child via breastfeeding. We investigated the presence of SARS-CoV-2 RNA in human milk samples of 15 mothers with coronavirus disease 19 (COVID-19) and in the throat swab samples of their infants. Methods This is a prospective observational study in which breast milk samples were collected from 15 mothers with COVID-19. The presence of SARS-CoV-2 RNA in the whole human milk samples of the patients was investigated using RT-qPCR. All of the infants underwent a clinical follow-up during their 14-day isolation and their throat swab samples were tested for SARS-CoV-2 RNA. Results Of 15 mothers with COVID-19, SARS-CoV-2 RNA was detected in milk samples from 4 mothers. The throat swab samples from these mothers' infants were found to be positive for SARS-CoV-2 RNA. Three of the four mothers were breastfeeding. In addition, during the 14-day isolation, all but three of the mothers breastfed their infants. Of the 12 breastfed infants, while the test for SARS-CoV-2 RNA in throat swab samples was negative in 6 of the infants, the other 6 infants, who had mild COVID-19 symptoms, tested positive for SARS-CoV-2 RNA. Clinical outcomes of all mothers and infants were uneventful. Conclusion To our knowledge, this is the first case series with the largest number of cases with SARS-CoV-2 RNA positivity in human milk samples of mothers with COVID-19. However, we believe that the benefits of breastfeeding may outweigh the risk of SARS-CoV-2 infection in infants.en_US
dc.identifier.doi10.1111/ijcp.14175
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue7en_US
dc.identifier.pmid33763939en_US
dc.identifier.scopus2-s2.0-85104385660en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14175
dc.identifier.urihttps://hdl.handle.net/11616/99887
dc.identifier.volume75en_US
dc.identifier.wosWOS:000640791600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleInvestigation of SARS-CoV-2 RNA in milk produced by women with COVID-19 and follow-up of their infants: A preliminary studyen_US
dc.typeArticleen_US

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