Histopathological evaluation of autopsy cases with isolated pulmonary fat embolism (IPFE): is cardiopulmonary resuscitation a main cause of death in IPFE?

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridÇelik, Muhammet Reha/0000-0001-8461-2909
dc.authoridPamukcu, Esra/0000-0002-5778-9626
dc.authoridozdemir kara, Dogus/0000-0002-3169-3538
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidÇelik, Muhammet Reha/AAZ-4455-2020
dc.authorwosidCelbiş, Osman/ABE-2803-2021
dc.authorwosidPamukcu, Esra/E-6427-2015
dc.authorwosidozdemir kara, Dogus/IRZ-8810-2023
dc.contributor.authorSamdanci, Emine Turkmen
dc.contributor.authorCelik, Muhammet Reha
dc.contributor.authorPehlivan, Sultan
dc.contributor.authorCelbis, Osman
dc.contributor.authorTurkkan, Dilhan
dc.contributor.authorKara, Dogus Ozdemir
dc.contributor.authorPamukcu, Esra
dc.date.accessioned2024-08-04T20:46:04Z
dc.date.available2024-08-04T20:46:04Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Fat embolism (FE) may develop following many traumatic and atraumatic clinical conditions; however, fewer data exist regarding the occurrence of isolated pulmonary FE (IPFE). Cardiopulmonary resuscitation (CPR) is an emergency procedure for maintaining blood circulation and oxygenation during cardiac arrest. In this study, we aimed to evaluate the association of CPR with IPFE in autopsy cases. Methods: A total 402 cases among 4,118 autopsies were diagnosed with IPFE, and the medical background of these cases was retrospectively evaluated. Diagnosis of FE and FE grading were performed with histopathological examinations of postmortem tissue samples, and injury-severity scores of traumatic cases were assessed. Data of traumatic and atraumatic cases were statistically compared. Results: Of the IPFE cases, 298 (741%) were male and 104 (25.9%) female, with overall mean age 53.7 (2-99) years. Causes of death of studied subjects were traumatic for 302 (75.1%) and atraumatic reasons for 100 (24.9%) cases. CPR was performed for 277 cases of which 177 (63.9%) were traumatic and 100 (36.1%) were non-traumatic. In comparison to traumatic cases, significantly higher CPR frequency was determined in atraumatic IPFE (P=0.001). High grade FE in the traumatic cases, and mild-moderate grade of FE in the nontraumatic cases were found statistically significant (P=0.001). Conclusion: This study indicates that CPR may be one of the leading factors in the development of IPFE in atraumatic conditions, and this procedure was related to mild-moderate IPFE manifestations. Regardless of whether conditions were traumatic or atraumatic, in patients who survive following CPR for manifest ventilation/perfusion problems, it should be remembered that IPFE may have developed due to CPR.en_US
dc.identifier.doi10.2147/OAEM.S194340
dc.identifier.endpage127en_US
dc.identifier.issn1179-1500
dc.identifier.pmid31239793en_US
dc.identifier.scopus2-s2.0-85069450090en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.2147/OAEM.S194340
dc.identifier.urihttps://hdl.handle.net/11616/98876
dc.identifier.volume11en_US
dc.identifier.wosWOS:000471097000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofOpen Access Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcardiopulmonary resuscitationen_US
dc.subjectCPRen_US
dc.subjectfat embolismen_US
dc.subjectpulmonary embolismen_US
dc.subjectautopsyen_US
dc.titleHistopathological evaluation of autopsy cases with isolated pulmonary fat embolism (IPFE): is cardiopulmonary resuscitation a main cause of death in IPFE?en_US
dc.typeArticleen_US

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