Effect of high-intensity exercise on endoplasmic reticulum stress and proinflammatory cytokine levels

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dc.authoridKORKMAZ, Kubranur/0000-0002-1593-4960
dc.authorwosidKORKMAZ, Kubranur/HGE-0470-2022
dc.contributor.authorKorkmaz, K.
dc.contributor.authorDuzova, H.
dc.contributor.authorTaslidere, A. Cetin
dc.contributor.authorKoc, A.
dc.contributor.authorKaraca, Z. M.
dc.contributor.authorDurmus, K.
dc.date.accessioned2024-08-04T20:53:27Z
dc.date.available2024-08-04T20:53:27Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. - High-intensity exercise impairs ER functions and elevates pro-inflammatory cytokines and neurotrophins levels. We investigated the effects of different intensity swimming exercises on ER stress of muscle damage with the impact of IL-23 and neurotrophic factors. Equipment and methods. - Rats were divided into three groups control (n = 9), normal swimming exercise (NSE) (n = 8), and weight-loaded swimming exercise (WLSE) (n = 9). Ventricle and skeletal muscle ATF4 and GRP78 levels were measured by Western Blot, and serum IL-17, IL-23, BDNF, NT-3, and NGF levels by ELISA method. Caspase-3 immunohistochemistry evaluation of skeletal muscle tissues was performed. Results. - The GRP78 level in the gastrocnemius muscle in the NSE group decreased, while the ATF4 level increased compared to other groups (P < 0.05). The ATF4 levels in heart muscle in the NSE group increased compared to the WLSE group (P < 0.05). The serum NT-3 level in the WLSE group rats increased compared to the other groups (P < 0.008). Intense Caspase-3 positive staining muscle cells were observed in the WLSE group compared to the control group (P <= 0.0001). Conclusions. - In response to high-intensity exercise, while pro-inflammatory cytokines, BDNF, and NGF adaptation in the body take place, also NT-3 secretion causing cell damage by the caspase system to cope with ER stress increasement is seen. In conclusion, this study shows us that high-intensity exercise may cause myopathy in the heart and skeletal muscle. (c) 2023 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipInonu University Scientific Research Foundation [2019-1747]en_US
dc.description.sponsorshipThe authors wish to thank Gil Bisra Kaya, Faruk Disli, Zeynep Rumeysa Yoldas & nbsp;, and Mesut Celik from Inonu University Faculty of Medicine, Department of Physiology, who provided technical support in conducting the study. Inonu University Scientific Research Foundation supported this research under a grant (Project number: (TYT, 2019-1747) .en_US
dc.identifier.doi10.1016/j.scispo.2022.04.009
dc.identifier.issn0765-1597
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85148755649en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.scispo.2022.04.009
dc.identifier.urihttps://hdl.handle.net/11616/101190
dc.identifier.volume38en_US
dc.identifier.wosWOS:001016413300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofScience & Sportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWeight-loading swimming exerciseen_US
dc.subjectER stressen_US
dc.subjectGRP78en_US
dc.subjectATF4en_US
dc.subjectIL-17en_US
dc.subjectIL-23en_US
dc.subjectBDNFen_US
dc.subjectNGFen_US
dc.subjectNT-3en_US
dc.subjectcaspase-3en_US
dc.titleEffect of high-intensity exercise on endoplasmic reticulum stress and proinflammatory cytokine levelsen_US
dc.typeArticleen_US

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