Evaluation of the genotoxicity and cytotoxicity in the buccal epithelial cells of patients undergoing orthodontic treatment with three light-cured bonding composites by using micronucleus testing

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dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorToy, Ebubekir
dc.contributor.authorYuksel, Sengul
dc.contributor.authorOzturk, Firat
dc.contributor.authorKaratas, Orhan Hakki
dc.contributor.authorYalcin, Vuhammet
dc.date.accessioned2024-08-04T20:39:42Z
dc.date.available2024-08-04T20:39:42Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study evaluated the cytotoxicity and genotoxicity of fixed orthodontic treatment with three different light-cured orthodontic bonding composites by analyzing micronucleus (MN) formation in the buccal mucosa during a 6-month period. Methods: Thirty healthy volunteers were selected from consecutive patients referred for orthodontic treatment. Equilibrium 2 brackets and molar tubes (Dentaurum) were bonded with three different lightcured orthodontic bonding composites Transbond XT (3M Unitek), Kurasper F (Kuraray Europe), or GrenGloo (Ormco Corporation) to all teeth in both arches. Exfoliated buccal epithelial cells were scraped from the middle part of the inner cheeks with sterile cement spatulas before treatment and at 1, 3, and 6 months after treatment. MNs and nuclear alterations, such as karyorrhexis (KR), karyolysis (KL), and binucleated cells (BNs), were scored under a light microscope. Repeated measure ANOVA was used to calculate statistical differences in degenerative nuclear abnormalities. Results: MN rates did not significantly differ among different time points within the same cell type (p > 0.05). in contrast, the number of BNs in buccal epithelial cells significantly increased in all composite groups (p < 0.01, Transbond XT; p < 0.001, Kurasper F and GrenGloo). KL frequency significantly increased between the beginning and end of the study in the Kurasfer F (0.80 + 0.79 to 1.90 + 1.10; p <0.05) and GrenGloo (1.30 + 1.06 to 2.40 + 1.08; p <0.05) groups. Conclusions: After 6 months of fixed orthodontic treatment with different light-cured composites, morphological signs of cytotoxicity were observed but genotoxic effects were absent.en_US
dc.identifier.doi10.4041/kjod.2014.44.3.128
dc.identifier.endpage135en_US
dc.identifier.issn2234-7518
dc.identifier.issn2005-372X
dc.identifier.issue3en_US
dc.identifier.pmid24892026en_US
dc.identifier.scopus2-s2.0-84901234671en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.4041/kjod.2014.44.3.128
dc.identifier.urihttps://hdl.handle.net/11616/96456
dc.identifier.volume44en_US
dc.identifier.wosWOS:000336239000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Assoc Orthodontistsen_US
dc.relation.ispartofKorean Journal of Orthodonticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenotoxicityen_US
dc.subjectCytotoxicityen_US
dc.subjectBuccal epithelial cellsen_US
dc.subjectOrthodontic compositesen_US
dc.subjectMicronucleus testen_US
dc.titleEvaluation of the genotoxicity and cytotoxicity in the buccal epithelial cells of patients undergoing orthodontic treatment with three light-cured bonding composites by using micronucleus testingen_US
dc.typeArticleen_US

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