Changes in hepatocellular carcinoma aggressiveness characteristics with an increase in tumor diameter

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dc.authoridFarinati, Fabio/0000-0002-2944-1374
dc.authoridPiscaglia, Fabio/0000-0001-8264-1845
dc.authoridOliveri, Filippo/0000-0002-9794-7203
dc.authoridVIDILI, GIANPAOLO/0000-0002-8903-5829
dc.authoridGiannini, Edoardo Giovanni/0000-0001-8526-837X
dc.authoridMega, Andrea/0000-0002-0458-3763
dc.authoridmorisco, filomena/0000-0002-9059-8311
dc.authorwosidCabibbo, Giuseppe/K-2966-2018
dc.authorwosidMorisco, Filomena/AHI-0851-2022
dc.authorwosidFarinati, Fabio/A-8267-2012
dc.authorwosidPiscaglia, Fabio/GRY-4468-2022
dc.authorwosidOliveri, Filippo/GRX-9884-2022
dc.authorwosidVIDILI, GIANPAOLO/JWP-7510-2024
dc.authorwosidGasbarrini, Antonio/AAB-8487-2019
dc.contributor.authorCarr, Brian I.
dc.contributor.authorGuerra, Vito
dc.contributor.authorDonghia, Rossella
dc.contributor.authorFarinati, Fabio
dc.contributor.authorGiannini, Edoardo G.
dc.contributor.authorPiscaglia, Fabio
dc.contributor.authorRapaccini, Gian Ludovico
dc.date.accessioned2024-08-04T20:50:13Z
dc.date.available2024-08-04T20:50:13Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Hepatocellular carcinoma prognosis depends on both liver and tumor determinants, especially on maximum tumor diameter, multifocality, and presence of portal vein thrombosis, despite apparently complete tumor removal by resection or liver transplantation. Aims: To examine parameters of hepatocellular carcinoma aggressiveness as tumor size increases. Methods: A large hepatocellular carcinoma database was examined for trends in serum alpha-fetoprotein and the percentage of patients with macroscopic portal vein thrombosis or tumor multifocality. Results: A total of 13,016 hepatocellular carcinoma patients were identified having full tumor and survival data. Of these, 76.56% were male and 23.44% were female, with a median age of 64.4 years. We found that as the maximum tumor diameter increased, there was a significant trend for increased alpha-fetoprotein levels (P<0.001) and an increased percentage of patients with either portal vein thrombosis or tumor multifocality, each P<0.0001. Furthermore, the increases of both alpha-fetoprotein and portal vein thrombosis were proportionately greater than the related maximum tumor diameter increases. These trends of increased alpha-fetoprotein, portal vein thrombosis, and multifocality with increasing maximum tumor diameter had non-linear patterns. Within alpha-fetoprotein and multifocality trends, there were identifiable sub-trends associated with specific maximum tumor diameter ranges. Conclusions: The greater fold-increases in alpha-fetoprotein and portal vein thrombosis compared with increases in maximum tumor diameter imply that hepatocellular carcinoma characteristics may change with increasing size to a more aggressive phenotype, suggesting that follow-up tumor sampling might be useful, in addition to baseline tumor sampling, for optimal therapeutic choices to be made.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported in part by NIH grant CA 82723 (B.I.C).en_US
dc.identifier.doi10.1177/1724600821996372
dc.identifier.endpage61en_US
dc.identifier.issn0393-6155
dc.identifier.issn1724-6008
dc.identifier.issue1en_US
dc.identifier.pmid33641486en_US
dc.identifier.scopus2-s2.0-85105391758en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1177/1724600821996372
dc.identifier.urihttps://hdl.handle.net/11616/99913
dc.identifier.volume36en_US
dc.identifier.wosWOS:000630580900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofInternational Journal of Biological Markersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHCCen_US
dc.subjectsizeen_US
dc.subjecttrenden_US
dc.subjectevolutionen_US
dc.titleChanges in hepatocellular carcinoma aggressiveness characteristics with an increase in tumor diameteren_US
dc.typeArticleen_US

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