Ghrelin prevents the development of dermal fibrosis in bleomycin-induced scleroderma

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dc.authoridUstundag, Bilal/0000-0001-6621-2450
dc.authorwosidKOCA, SULEYMAN SERDAR/HJY-2666-2023
dc.authorwosidÜSTÜNDAĞ, BİLAL/V-9780-2018
dc.contributor.authorKoca, S. S.
dc.contributor.authorOzgen, M.
dc.contributor.authorSarikaya, M.
dc.contributor.authorDagli, F.
dc.contributor.authorUstundag, B.
dc.contributor.authorIsik, A.
dc.date.accessioned2024-08-04T20:38:03Z
dc.date.available2024-08-04T20:38:03Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundScleroderma is a chronic inflammatory disease characterized by widespread fibrosis of the skin and the internal organs. Ghrelin is a polypeptide hormone produced by various tissues and inflammatory cells. In experimental studies, ghrelin has been shown to have anti-inflammatory and antioxidant effects, in addition to its metabolic actions. AimTo evaluate the potential preventive effects of ghrelin on a mouse model of bleomycin (BLM)-induced scleroderma. MethodsThis study involved five groups of BALB/c mice (n=7 in each group). Mice in the control group received 100L/day of phosphate-buffered saline (PBS) subcutaneously, while the other four groups were given 100g/day of BLM (dissolved in 100L PBS) subcutaneously. Three of the BLM-treated groups received intraperitoneal doses (10ng/kg/day) of acylated, nonacylated or total ghrelin. Animals were killed at the end of the fourth week, and blood and tissue samples were collected for further analysis. Dermal thickness, serum levels of transforming growth factor-1, numbers of inflammatory cells on the dermal layer and numbers of -smooth muscle actin-positive cells were determined. ResultsBLM increased dermal thickness, numbers of inflammatory cells on the dermal layer and activity of the myofibroblastic cells. Application of acylated, nonacylated and total ghrelin decreased the infiltration of inflammatory cells and the activity of the myofibroblastic cells, and reduced dermal fibrosis. ConclusionsBased on these results, it appears that ghrelin has an antifibrotic action, in addition to the anti-inflammatory and antioxidant effects that have been documented previously. The pathogenic and therapeutic roles of ghrelin in scleroderma should be evaluated by further studies.en_US
dc.identifier.doi10.1111/ced.12195
dc.identifier.endpage181en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue2en_US
dc.identifier.pmid24033834en_US
dc.identifier.scopus2-s2.0-84894084673en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage176en_US
dc.identifier.urihttps://doi.org/10.1111/ced.12195
dc.identifier.urihttps://hdl.handle.net/11616/96349
dc.identifier.volume39en_US
dc.identifier.wosWOS:000331183400012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrowthen_US
dc.subjectCellsen_US
dc.subjectReceptoren_US
dc.subjectInjuryen_US
dc.subjectInterleukin-2en_US
dc.subjectProliferationen_US
dc.subjectExpressionen_US
dc.titleGhrelin prevents the development of dermal fibrosis in bleomycin-induced sclerodermaen_US
dc.typeArticleen_US

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