Melatonin elicits protein kinase C-mediated calcium response in immortalized GT1-7 GnRH neurons

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dc.authoridOzcan, Mete/0000-0002-5551-4880
dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authorwosidAYAR, Ahmet/I-1379-2014
dc.authorwosidOzcan, Mete/V-8758-2018
dc.authorwosidKelestimur, Haluk/V-9392-2018
dc.authorwosidKacar, Emine/W-1487-2018
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.contributor.authorKelestimur, Haluk
dc.contributor.authorOzcan, Mete
dc.contributor.authorKacar, Emine
dc.contributor.authorAlcin, Ergul
dc.contributor.authorYilmaz, Bayram
dc.contributor.authorAyar, Ahmet
dc.date.accessioned2024-08-04T20:35:43Z
dc.date.available2024-08-04T20:35:43Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMelatonin is suggested to have effects on hypothalamic-pituitary-gonadal (HPG) axis. The pulsatile pattern of GnRH release, which results in the intermittent release of gonadotropic hormones from the pituitary, has a critical importance for reproductive function but the factors responsible from this release pattern are not known. Calcium is a second messenger involved in hormone release. Therefore, investigation of the effects of melatonin on intracellular free calcium levels ([Ca2+](i)) would provide critical information on hormone release in immortalized GnRH neurons. The pattern of melatonin-induced intracellular calcium signaling was investigated by fluorescence calcium imaging using the immortalized GnRH-secreting GT1-7 hypothalamic neurons. Melatonin caused a significant increase in [Ca2+](i), which was greatly blocked by luzindole, a melatonin antagonist, or attenuated by pre-treatment with protein kinase C inhibitor. This study suggests that melatonin seems to have a direct effect on GnRH neurons. (C) 2011 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [107T825]en_US
dc.description.sponsorshipWe thank Dr. Pamela L. Mellon, Department of Reproductive Medicine, University of California, San Diego, for kindly providing GT1-7 cells. This work was supported by a grant from TUBITAK (Project No. 107T825).en_US
dc.identifier.doi10.1016/j.brainres.2011.11.040
dc.identifier.endpage28en_US
dc.identifier.issn0006-8993
dc.identifier.pmid22177776en_US
dc.identifier.scopus2-s2.0-84856396804en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2011.11.040
dc.identifier.urihttps://hdl.handle.net/11616/95554
dc.identifier.volume1435en_US
dc.identifier.wosWOS:000301318400004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectCalcium signalingen_US
dc.subjectGT1-7 cellen_US
dc.titleMelatonin elicits protein kinase C-mediated calcium response in immortalized GT1-7 GnRH neuronsen_US
dc.typeArticleen_US

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