Effects of high-voltage electrical burns and other burns on levels of serum oxidative stress and telomerase in children

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridUremis, Muhammed/0000-0003-2296-2422
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridTaşçı, Aytaç/0000-0002-4024-5219
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidUremis, Muhammed/V-5830-2019
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidTaşçı, Aytaç/AAA-2857-2021
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorDemircan, Mehmet
dc.contributor.authorTasci, Aytac
dc.contributor.authorUremia, Muhammed Mehdi
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:44:39Z
dc.date.available2024-08-04T20:44:39Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Electrical burns cause significant morbidity and mortality worldwide. Here we measured changes in levels of serum oxidative stress and telomerase in children suffering from high-voltage electrical burn (HVEB) injuries and other burns and the significance of these parameters in terms of amputation. Materials and methods: After obtaining approval from our ethics committee for this prospective study, we formed three groups: a group of 18 children with HVEBs, a group of 18 children with thermal burns, and a control group. All children were 1-16 years of age. The HVEB group was divided into HVEB-WA (without amputation) and HVEB-A (with amputation) subgroups. Serum malondialdehyde (MDA) level, total antioxidant capacity (TAC), total oxidant capacity (TOC), glutathione (GSH) level, and telomerase level were measured and compared among the groups. Results: The patients differed in terms of demographics. The healing time of the HVEB group was longer than that of the thermal burn group, and the oxidative stress indicators of the HVEB group remained higher for longer. The mean oxidative stress indices in the HVEB-A group were higher than those in the HVEB-WA group and remained elevated for longer. Conclusion: HVEBs are more destructive than thermal burns; damage may progress over time, and healing takes longer. Healing can be followed biochemically by measuring levels of oxidative stress indicators. Indications for amputation, if not initially obvious, can be predicted by evaluating these indicators, affording therapeutic advantages. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.identifier.doi10.1016/j.burns.2018.07.001
dc.identifier.endpage2041en_US
dc.identifier.issn0305-4179
dc.identifier.issn1879-1409
dc.identifier.issue8en_US
dc.identifier.pmid30049506en_US
dc.identifier.scopus2-s2.0-85050191063en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2034en_US
dc.identifier.urihttps://doi.org/10.1016/j.burns.2018.07.001
dc.identifier.urihttps://hdl.handle.net/11616/98388
dc.identifier.volume44en_US
dc.identifier.wosWOS:000451331200022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBurnsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrical injuryen_US
dc.subjectElectrical burnsen_US
dc.subjectBurnsen_US
dc.subjectChildrenen_US
dc.subjectOxidative stressen_US
dc.subjectSystemic inflammatory reactionen_US
dc.subjectTelomeraseen_US
dc.subjectMalondialdehydeen_US
dc.subjectTotal antioxidant capacityen_US
dc.subjectGlutathioneen_US
dc.titleEffects of high-voltage electrical burns and other burns on levels of serum oxidative stress and telomerase in childrenen_US
dc.typeArticleen_US

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