Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Turkiye

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dc.authoridAslan-Kara, Kezban/0000-0002-3868-9814
dc.authoridkeskin güler, selda/0000-0003-1976-7319
dc.authoridVelioglu, Sibel K/0000-0003-0352-702X
dc.authoridTekin, Betül/0000-0002-8946-6952
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridAtalar, Arife Çimen/0000-0003-0328-9607
dc.authoridTutkavul, Kemal/0000-0002-0986-3924
dc.authorwosidAslan-Kara, Kezban/V-1608-2018
dc.authorwosidkeskin güler, selda/AAN-6081-2021
dc.authorwosidCEYHAN DİRİCAN, AYTEN/JKI-6515-2023
dc.authorwosidVelioglu, Sibel K/V-3899-2017
dc.authorwosidGENÇ, FATMA/AEO-2017-2022
dc.authorwosidTekin, Betül/AFM-8600-2022
dc.authorwosidüstün özek, sibel/AFP-3737-2022
dc.contributor.authorPekoz, Mehmet Taylan
dc.contributor.authorAslan-Kara, Kezban
dc.contributor.authorTekin, Betul
dc.contributor.authorGurses, Candan
dc.contributor.authorYeni, Seher Naz
dc.contributor.authorBozdemir, Hacer
dc.contributor.authorKeskin-Guler, Selda
dc.date.accessioned2024-08-04T20:54:31Z
dc.date.available2024-08-04T20:54:31Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectiveThe present study was aimed at investigating the effects of anti-seizure medications (ASMs), patient demographic characteristics, and the seizure type and frequency on the development of congenital malformations (CMs) in the infants of pregnant women with epilepsy (PWWE).MethodsPWWE followed up at the neurology outpatient clinic of 21 centers between 2014 and 2019 were included in this prospective study. The follow-up of PWWE was conducted using structured, general pregnant follow-up forms prepared by the Pregnancy and Epilepsy Study Committee. The newborns were examined by a neonatologist after delivery and at 1 and 3 months postpartum.ResultsOf the infants of 759 PWWE, 7.2% had CMs, with 5.6% having major CMs. Polytherapy, monotherapy, and no medications were received by 168 (22.1%), 548 (72.2 %), and 43 (5.7 %) patients, respectively. CMs were detected at an incidence of 2.3% in infants of PWWE who did not receive medication, 5.7% in infants of PWWE who received monotherapy, and 13.7% in infants of PWWE who received polytherapy. The risk of malformation was 2.31-fold (95% confidence interval (CI): 1.48-4.61, p < .001) higher in infants of PWWE who received polytherapy. Levetiracetam was the most frequently used seizure medication as monotherapy, with the highest incidence of CMs occurring with valproic acid (VPA) use (8.5%) and the lowest with lamotrigine use (2.1%). The incidence of CMs was 5% at a carbamazepine dose <700 mg, 10% at a carbamazepine dose & GE;700 mg, 5.5% at a VPA dose <750 mg, and 14.8% at a VPA dose =750 mg. Thus the risk of malformation increased 2.33 times (p = .041) in infants of PWWE receiving high-dose ASMs.SignificanceBirth outcomes of PWWE receiving and not receiving ASMs were evaluated. The risk of CMs occurrence was higher, particularly in infants of PWWE using VPA and receiving polytherapy. The incidence of CMs was found to be lower in infants of PWWE receiving lamotrigine.en_US
dc.identifier.doi10.1111/epi.17692
dc.identifier.endpage2321en_US
dc.identifier.issn0013-9580
dc.identifier.issn1528-1167
dc.identifier.issue9en_US
dc.identifier.pmid37357418en_US
dc.identifier.scopus2-s2.0-85165272909en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2310en_US
dc.identifier.urihttps://doi.org/10.1111/epi.17692
dc.identifier.urihttps://hdl.handle.net/11616/101476
dc.identifier.volume64en_US
dc.identifier.wosWOS:001029932900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEpilepsiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-seizure medicationsen_US
dc.subjectcongenital malformationen_US
dc.subjectpregnant women with epilepsyen_US
dc.subjectteratogenicityen_US
dc.titleBirth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Turkiyeen_US
dc.typeArticleen_US

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