Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridArmutcu, Ferah/0000-0002-3218-9480
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.contributor.authorYildirim, Z
dc.contributor.authorTurkoz, Y
dc.contributor.authorKotuk, M
dc.contributor.authorArmutcu, F
dc.contributor.authorGurel, A
dc.contributor.authorIraz, M
dc.contributor.authorOzen, S
dc.date.accessioned2024-08-04T20:31:05Z
dc.date.available2024-08-04T20:31:05Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractReactive oxygen and nitrogen species have been implicated in the pathogenesis of bleomycin -induced lung fibrosis. The effects of aminoguanidine and erdosteine on the bleomycin-induced lung fibrosis were evaluated in rats. The animals were placed into five groups: Vehicle + vehicle, vehicle + bleomycin (2.5U/kg), bleomycin + aminoguanidine (200mg/kg), bleomycin + erdosteine (10mg/kg), and bleomycin + erdosteine + aminoguanidine. Bleomycin administration resulted in prominent lung fibrosis as measured by lung hydroxyproline content and lung histology, which is completely prevented by erdosteine and aminoguanidine. A strong staining for nitro tyrosine antibody in lung tissue and increased levels of lung NO were found in bleomycin group, that were significantly reduced by aminoguanidine and erdosteine. Aminoguanidine and erdosteine significantly prevented depletion of superoxide dismutase and glutathione peroxidase and elevated myeloperoxidase activities, malondialdehyde level in lung tissue produced by bleomycin. Data presented here indicate that aminoguanidine and erdosteine prevented bleomycin-induced lung fibrosis and that nitric oxide mediated tyrosine nitration of proteins plays a significant role in the pathogenesis of bleomycin-induced lung fibrosis. Also our data suggest that antifibrotic affect of antioxidants may be due to their inhibitory effect on nitric oxide generation in this model. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.niox.2004.07.011
dc.identifier.endpage165en_US
dc.identifier.issn1089-8603
dc.identifier.issue2en_US
dc.identifier.pmid15491848en_US
dc.identifier.scopus2-s2.0-5644232445en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage156en_US
dc.identifier.urihttps://doi.org/10.1016/j.niox.2004.07.011
dc.identifier.urihttps://hdl.handle.net/11616/94702
dc.identifier.volume11en_US
dc.identifier.wosWOS:000224996700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofNitric Oxide-Biology and Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbleomycinen_US
dc.subjectlung fibrosisen_US
dc.subjectnitric oxideen_US
dc.subjectaminoguanidinen_US
dc.subjecterdosteineen_US
dc.titleEffects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in ratsen_US
dc.typeArticleen_US

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