Subclinical diastolic dysfunction in children with Wilson s disease assessed by tissue Doppler echocardiography a possible early predictor of cardiac involvement

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dc.authorid113476en_US
dc.authorid113274en_US
dc.authorid9712en_US
dc.contributor.authorElkıran, Özlem
dc.contributor.authorKarakurt, Cemşit
dc.contributor.authorSelimoğlu, Ayşe
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorKoçak, Gülemdar
dc.contributor.authorÇelik, Faruk Serkan
dc.contributor.authorÇolak, Cemil
dc.date.accessioned2017-12-22T10:19:58Z
dc.date.available2017-12-22T10:19:58Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.descriptionActa cardiologicaen_US
dc.description.abstractBackground The aim of this study was to evaluate the left ventricular systolic and diastolic functions and cardiac rhythm problems for the early detection of myocardial dysfunction in children with Wilson’s disease. Methods We compared patients who had Wilson’s disease (n = 22) with age- and sex-matched healthy control subjects (n = 21). The diagnosis of Wilson’s disease was based on clinical symptoms and laboratory tests (serum ceruloplasmin, urinary and hepatic copper concentrations). Standard echocardiographic examination, as well as pulsed-wave Doppler, tissue Doppler echocardiography examinations of all patients were performed. 24-hour ECG Holter monitoring was also performed in all subjects. Results All patients were asymptomatic on cardiological examination and had sinus rhythm on electrocardiography. Left ventricular ejection fraction, fractional shortening, wall thickness and left ventricular mass were similar in both groups. In comparison to healthy subjects, children with Wilson’s disease had signifi cantly lower mitral E velocity, mitral E/A ratio (P = 0.046, P= 0.021, respectively) and longer isovolumetric relaxation time values (P = 0.015) as estimated by pulsed wave Doppler echocardiography. Wilson patients had longer isovolumetric relaxation time (IVRT) values estimated by tissue Doppler echocardiography (P = 0.006) compared to the controls. On 24-hour ECG Holter monitoring, none of the Wilson patients showed life-threatening cardiac arrhythmia. Conclusion Our study showed results that might be consistent with subclinical diastolic dysfunction in cardiologically asymptomatic Wilson’s disease children which probably represents an early stage of cardiac involvement. Therefore it may be useful to monitor these signs in the follow-up of the patients.en_US
dc.identifier.citationElkiran, O., Karakurt, C., Selimoglu, A., Karabibe, H., Kocak, G., Celik, S.F., Colak, C. (2013). Subclinical diastolic dysfunction in children with Wilson s disease assessed by tissue Doppler echocardiography a possible early predictor of cardiac involvement. Acta cardiologica.en_US
dc.identifier.endpage0en_US
dc.identifier.issue2en_US
dc.identifier.startpage0en_US
dc.identifier.urihttp://www.tandfonline.com/doi/abs/10.1080/AC.68.2.2967276
dc.identifier.urihttps://hdl.handle.net/11616/7923
dc.identifier.volume68en_US
dc.language.isoenen_US
dc.publisherActa cardiologicaen_US
dc.relation.ispartofActa cardiologicaen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectWilson’s diseaseen_US
dc.subjectChildrenen_US
dc.subjectTissue Doppler echocardiographyen_US
dc.titleSubclinical diastolic dysfunction in children with Wilson s disease assessed by tissue Doppler echocardiography a possible early predictor of cardiac involvementen_US
dc.typeArticleen_US

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