Serum electrolytes and nitric oxide levels in acute hypotension following intravenous heparin

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dc.authorscopusid55666804700
dc.authorscopusid8861779800
dc.authorscopusid8932188900
dc.authorscopusid12780286100
dc.authorscopusid8842895700
dc.authorscopusid7004486274
dc.contributor.authorToprak H.I.
dc.contributor.authorBegec Z.
dc.contributor.authorBut A.
dc.contributor.authorSizanli E.
dc.contributor.authorBayraktar N.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T20:02:11Z
dc.date.available2024-08-04T20:02:11Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHeparin is frequently used as an anticoagulant agent for patients undergoing surgery with cardiopulmonary bypass. In literature, severe hypotension as a side effect of high dose bolus heparin has been already reported. However, the exact mechanism of hypotension has not yet fully been understood. The aim of the study was to investigate the relationship between hemodynamic instability induced by heparin and levels of serum electrolytes and nitric oxide. Forty patients undergoing elective coronary artery bypass grafting were included into the study. Patients with sudden decrease in mean arterial pressure (MAP) higher than 25 % of the baseline after heparin administration were included into group H (n=20). Besides, consecutive twenty hemodinamically stabile patients (with none or a MAP decrease lower than 25 % of baseline) constituted group N (n=20). Anesthetic techniques were standardized. Arterial blood gases were analyzed for pH, PaO2, PaCO2, potassium, sodium, calcium, magnesium, hematocrit before and 5 minutes after heparin administration. Synchronous serum nitric oxide levels analysis were also performed. The nitric oxide levels were measured as reflected by the formation of its stable end-metabolites, nitrite and nitrate. Serum electrolyte and nitric oxide levels were not statistically different neither between before and after heparin administration nor between hypotension group and normotension group. Hypotension observed after heparin administration was not related with the concentration of serum electrolytes and nitric oxide.en_US
dc.identifier.endpage163en_US
dc.identifier.issn1305-5550
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-33847673221en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://hdl.handle.net/11616/91498
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofGogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectElectrolytesen_US
dc.subjectHeparinen_US
dc.subjectHypotensionen_US
dc.subjectNitric oxideen_US
dc.titleSerum electrolytes and nitric oxide levels in acute hypotension following intravenous heparinen_US
dc.title.alternativeHeparine ba?li gelişen akut hipotansiyonda serum elektrolit ve nitrik oksit düzeylerien_US
dc.typeArticleen_US

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