Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus

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dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridozcan, abdulcemal/0000-0002-6759-7556;
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidSaraç, Kaya/ABI-1091-2020
dc.contributor.authorSarac, K
dc.contributor.authorAkinci, A
dc.contributor.authorAlkan, A
dc.contributor.authorAslan, M
dc.contributor.authorBaysal, T
dc.contributor.authorÖzcan, C
dc.date.accessioned2024-08-04T20:14:53Z
dc.date.available2024-08-04T20:14:53Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9 +/- 3.4 (8.2-19.4). The average number of keto-acidosis episodes was 1.9 +/- 2.2 (0-9) and the average number of daily insulin injections was 2.8 +/- 0.97 (2-4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover.en_US
dc.identifier.doi10.1007/s00234-005-1387-3
dc.identifier.endpage565en_US
dc.identifier.issn0028-3940
dc.identifier.issn1432-1920
dc.identifier.issue7en_US
dc.identifier.pmid15973536en_US
dc.identifier.scopus2-s2.0-23144432419en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage562en_US
dc.identifier.urihttps://doi.org/10.1007/s00234-005-1387-3
dc.identifier.urihttps://hdl.handle.net/11616/94033
dc.identifier.volume47en_US
dc.identifier.wosWOS:000230653400012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeuroradiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttype 1 diabetes mellitusen_US
dc.subjectbrainen_US
dc.subjectMR spectroscopyen_US
dc.titleBrain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitusen_US
dc.typeArticleen_US

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