The inhibitory effects of taxifolin, namely dihydroquercetin as a pharmaceutical agent on the growth of bacterial and fungal species

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dc.contributor.authorÜnver, Tuba
dc.date.accessioned2024-08-04T19:42:44Z
dc.date.available2024-08-04T19:42:44Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Taxifolin (dihydroquercetin) is a natural bioactive flavonoid with antifungal, antiviral, antibacterial, antioxidant, and anti-inflammatory properties, and is a valuable compound in the medical, pharmaceutical, and food industries. This study aims to determine the Minimum Inhibitory Concentration (MIC) of pure taxifolin (99.25%) against pathogenic and opportunistic microorganisms. Materials and Methods: The antibacterial and antifungal activities of taxifolin against two Gram-positive (E. aerogenes, S. aureus), three Gram-negative (P. aeruginosa, K. pneumonia and E. coli), and four yeast strains (C. krusei, C. glabrata, C. tropicalis and C. albicans) was determined using agar and broth microdilution methods. Results: The MIC value for tested Gram-positive bacteria is 1 mg/mL, which is 2 mg/ml for Gram-negative bacteria. At the same time, the MIC value was 8 mg/mL for all Candida species tested except C. glabrata (MIC: 4 mg/mL). Conclusion: In conclusion, it was determined that the antibacterial property of taxifolin was more pronounced than its antifungal properties. Taxifolin is a natural compound with high medical and pharmacological value. This study proved the effectiveness of pure taxifolin as a pharmacotherapeutic agent on pathogenic and opportunistic microorganisms. The preliminary data collected in this study should be further supported, and in vivo and bioavailability studies should be detailed in future studies.en_US
dc.identifier.doi10.5455/annalsmedres.2024.01.017
dc.identifier.endpage227en_US
dc.identifier.issn2636-7688
dc.identifier.issue3en_US
dc.identifier.startpage222en_US
dc.identifier.trdizinid1229259en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2024.01.017
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1229259
dc.identifier.urihttps://hdl.handle.net/11616/88645
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe inhibitory effects of taxifolin, namely dihydroquercetin as a pharmaceutical agent on the growth of bacterial and fungal speciesen_US
dc.typeArticleen_US

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