'Is RLS a harbinger and consequence of MS?: Striking results of the 'RELOMS-T' study'

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dc.authoridSiva, Aksel/0000-0002-8340-6641
dc.authoridTERZİ, Murat/0000-0002-3586-9115
dc.authoridGOKSEL, BASAK KARAKURUM/0000-0003-2766-2277
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridEkmekçi, Özgül/0000-0001-8633-9416
dc.authoridşen, sedat/0000-0001-8048-6845
dc.authoridDemirkiran, Meltem/0000-0002-4649-5315
dc.authorwosidSiva, Aksel/A-5132-2016
dc.authorwosidTERZİ, Murat/AAA-1284-2021
dc.authorwosidSevim, Serhan/KBA-7417-2024
dc.authorwosidGOKSEL, BASAK KARAKURUM/AAE-2609-2021
dc.authorwosidKurtuncu, Murat/L-2705-2015
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidKarabudak, Rana/HJH-2490-2023
dc.contributor.authorSevim, Serhan
dc.contributor.authorDemirkiran, Meltem
dc.contributor.authorTerzi, Murat
dc.contributor.authorYuceyar, Nur
dc.contributor.authorTasdelen, Bahar
dc.contributor.authorIdiman, Egemen
dc.contributor.authorKurtuncu, Murat
dc.date.accessioned2024-08-04T20:47:22Z
dc.date.available2024-08-04T20:47:22Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Although studies report a high prevalence rate of restless legs syndrome (RLS) among patients with multiple sclerosis (PwMS) ranging from 13.3 to 65.1%, little is known about the causes of this relationship. Methods: To ascertain the prevalence, features and impact of RLS among PwMS a nation-wide, multicenter, prospective and a cross-sectional survey, designed to reflect all of the PwMS throughout Turkey, was conducted in 13 centers. Exploring the relationship of the two conditions could possibly contribute to the understanding of the causes of the high and wide-ranging prevalence rates and the pathophysiology of both diseases. Results: Of the 1068 participants 173 (16,2%) found to have RLS [RLS(+)] and 895 (83,8%) did not [RLS(-)]. Among the RLS(+) 173, all but 8 patients (4,6%) were underdiagnosed in terms of RLS. More than half of the patients with RLS had 'severe' or 'very severe' RLS. The onset of RLS was before or synchronous with the onset of MS in about a half of our patients. Conclusion: We conclude that RLS should be meticulously investigated in PwMS and MS can be a direct cause of RLS at least in part of PwMS. Our data about the timing of the onset of MS and RLS, along with the high prevalence of RLS in PwMS suggest that the pathologic changes in the initial phases of MS can possibly trigger RLS symptoms.en_US
dc.identifier.doi10.1016/j.msard.2020.102055
dc.identifier.issn2211-0348
dc.identifier.issn2211-0356
dc.identifier.pmid32473575en_US
dc.identifier.scopus2-s2.0-85085323057en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.msard.2020.102055
dc.identifier.urihttps://hdl.handle.net/11616/99308
dc.identifier.volume42en_US
dc.identifier.wosWOS:000544066300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofMultiple Sclerosis and Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectRestless legs syndromeen_US
dc.subjectEpidemiologyen_US
dc.subjectSpinal corden_US
dc.subjectPathophysiologyen_US
dc.title'Is RLS a harbinger and consequence of MS?: Striking results of the 'RELOMS-T' study'en_US
dc.typeArticleen_US

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