Tear film osmolarity in patients with thyroid ophthalmopathy

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dc.contributor.authorIskeleli, Guzin
dc.contributor.authorKarakoc, Yunus
dc.contributor.authorAbdula, Arzu
dc.date.accessioned2024-08-04T20:30:58Z
dc.date.available2024-08-04T20:30:58Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To compare tear film osmolarity between patients with thyroid ophthalmopathy and normal healthy subjects. Methods: The tear film osmolarity in 15 normal subjects (15 eyes) (control group) and 21 patients (21 eyes) with thyroid ophthalmopathy was evaluated. Tear film osmolarity in milliosmole (mOsm) was determined by using an auto-osmometer. The palpebral fissure width, degree of proptosis, and tear break-up time (BUT) were also determined. The results for the two groups were compared statistically. Results: The mean palpebral fissure width was 9.13 +/- 0.74 mm in the healthy subjects and 13.33 +/- 1.55 mm in the thyroid ophthalmopathy patients. This difference was statistically significant (P = 0.0001). The mean proptosis was 15.33 +/- 1.39 Hertel units in the healthy subjects and 20.71 +/- 0.95 Hertel units in the patients. This difference was also statistically significant (P = 0.0001). The mean tear BUT was 6.35 +/- 1.56 s in the patients and 18.27 +/- 1.53 s in the healthy subjects, and this difference was also statistically significant (P = 0.0005). The mean tear film osmolarity was 290.80 +/- 13.58 mOsm in the healthy subjects and 340.38 +/- 18.74 mOsm in the patients. There was a statistically significant difference between the groups (P = 0.0001). Conclusions: The significantly higher tear film osmolarity in patients with thyroid ophthalmopathy was most likely due to the increased proptosis and lid fissure width. These conditions may lead to injury of the ocular surface.en_US
dc.identifier.doi10.1007/s10384-008-0545-7
dc.identifier.endpage326en_US
dc.identifier.issn0021-5155
dc.identifier.issue4en_US
dc.identifier.pmid18773272en_US
dc.identifier.scopus2-s2.0-51349084575en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.1007/s10384-008-0545-7
dc.identifier.urihttps://hdl.handle.net/11616/94643
dc.identifier.volume52en_US
dc.identifier.wosWOS:000258960200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Tokyoen_US
dc.relation.ispartofJapanese Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttear film osmolarityen_US
dc.subjectthyroid ophthalmopathyen_US
dc.titleTear film osmolarity in patients with thyroid ophthalmopathyen_US
dc.typeArticleen_US

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