Effectiveness of tibolone on hypoestrogenic symptoms induced by goserelin treatment in patients with endometriosis

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dc.authoridBuhur, Ali/0000-0003-1228-0962;
dc.authorwosidBuhur, Ali/GLQ-5966-2022
dc.authorwosidtaskin, omur/C-6864-2016
dc.contributor.authorTaskin, O
dc.contributor.authorUryan, I
dc.contributor.authorYalcinoglu, AI
dc.contributor.authorBuhur, A
dc.contributor.authorKucuk, S
dc.contributor.authorBurak, F
dc.date.accessioned2024-08-04T20:11:53Z
dc.date.available2024-08-04T20:11:53Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description51st Annual Meeting of the American-Society-for-Reproductive-Medicine -- OCT 07-13, 1995 -- SEATTLE, WAen_US
dc.description.abstractObjective: To investigate the efficacy and safety of tibolone on hypoestrogenic vasomotor symptoms and bone parameters in patients treated with goserelin acetate. Design: Prospective, randomized placebo controlled double-blind study. Setting: Human volunteers in a university-based fertility clinic. Patient(s): Twenty-nine women of mean age 29.2 +/- 4.8 years with mild to severe endometriosis undergoing 6 months of treatment with 3.6 mg goserelin acetate in an SC depot formulation were studied. Intervention(s): The patients were allocated randomly to either 2.5 mg/d tibolone (n = 15) or an iran pill (n = 14) in a double-blinded fashion beginning in the third cycle. Main Outcome Measure(s): Frequency and severity of hot flushes, sweating, irritability, loss of libido, nervousness, and sleeplessness were assessed by the patients using 0 to 6 point scoring system and compared. Samples of urine were obtained for calcium and creatinine (Ca:Cr) ratios at the start of treatment and monthly there after. The vasomotor scoring for each symptom and Ca:Cr ratios before the treatment and at the end of 6th month were analyzed by parametric: and nonparametric tests. Result(s): The mean age, weight, vasomotor scores, pelvic scores, and urine Ca:Cf ratios were similar in both placebo and tibolone group (28.7 +/- 4.8 versus 27.6 +/- 6.3 years, 50.9 +/- 5,3 versus 53.1 +/- 7.1 Bg, 4.7 +/- 1,1 versus 4.2 +/- 0.8, and 0.056 +/- 0.008 versus 0.059 +/- 0.006, respectively). The decreases in vasomotor scoring as regards to hot flushing, sweating, and other associated symptoms were statistically significant in tibolone group compared with placebo (10.4 +/- 1.6 versus 24.6 +/- 4.9). During the study significant reductions in urine Ca:Cr ratio was obtained in the tibolone patients compared with placebo (0.031 +/- 0.006 versus 0.0055 +/- 0.007). The incidence of side effects (weight change, vaginal bleeding) was low and did not differ from the placebo group. Conclusion(s): Considering the beneficial effects of tibolone on vasomotor symptoms and bone loss, our data suggest that this synthetic steroid is an effective and safe option in relieving symptoms induced by GnRH-analogue.en_US
dc.description.sponsorshipAmer Soc Reprod Meden_US
dc.identifier.doi10.1016/S0015-0282(97)81853-5
dc.identifier.endpage45en_US
dc.identifier.issn0015-0282
dc.identifier.issue1en_US
dc.identifier.pmid8986681en_US
dc.identifier.scopus2-s2.0-0031019505en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.1016/S0015-0282(97)81853-5
dc.identifier.urihttps://hdl.handle.net/11616/93075
dc.identifier.volume67en_US
dc.identifier.wosWOS:A1997VZ99400008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Soc Reproductive Medicineen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGnRH-aen_US
dc.subjecttiboloneen_US
dc.subjecthypoestrogenismen_US
dc.subjectendometriosisen_US
dc.subjectadd-back therapyen_US
dc.titleEffectiveness of tibolone on hypoestrogenic symptoms induced by goserelin treatment in patients with endometriosisen_US
dc.typeConference Objecten_US

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